Lazabemide hydrochloride
Lazabemide hydrochloride(N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid)
CAS: 103878-83-7
化学式: C8H10ClN3O.HCl
| 中文名 | Lazabemide hydrochloride |
| 英文名 | N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid |
| 别名 | 拉扎贝胺盐酸盐 |
| 英文别名 | TeMpiuM Lazabemide hydrochloride JMFKTFLARGGXCC-UHFFFAOYSA-N N-(2-Aminoethyl)-5-chlor-2-pyridincarbox N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride 2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-, Monohydrochloride |
| CAS | 103878-83-7 |
| 化学式 | C8H10ClN3O.HCl |
| 分子量 | 236.1 |
| 熔点 | 193-195° |
| 酸度系数 | 8.9(at 25℃) |
| 存储条件 | Desiccate at RT |
| 体外研究 | The in vitro binding characteristics of both radiolabeled inhibitors revealed them to be selective, high-affinity ligands for the respective enzymes. K D and B max values for 3 H-Ro 19-6327 in rat cerebral cortex are 18.4 nM and 3.45 pmol/mg protein, respectively. The IC 50 values for lazabemide are: 86 μM for NA uptake; 123 μM for 5HT uptake; > 500 μM for DA uptake, respectively.. Lazabemide (5 μM) inhibits human MAO-B and MAO-A with IC 50 of 6.9 nM and >10 nM, respectively. And it inhibits rat MAO-B and MAO-A with IC 50 of 37 nM and >10 μM, respectively ina enzymatic assay.Lazabemide differs from L-deprenyl in their ability to induce release of endogenous monoamines from synaptosomes. Thus, Lazabemide (500 μM) induces a greater 5 HT release than does L-deprenyl, but is less effective than L-deprenyl in releasing DA. On the contrary, lazabemide was almost completely inactive on either 5 HT and DA release. Lazabemide (250 nM) results in a clear inhibition of DOPAC formation, while does not increase the accumulation of newly-formed DA in those tubular epithelial cells loaded with 50 microM L-DOPA. |
| 体内研究 | Lazabemide (3 mg/kg) attenuates ichemia reperfusion-induced hydroxyl radical generation and pretreatment with Lazabemide showed decreased DOPAC levels in comparison with those of their respective vehicle-treated control groups. |
Lazabemide hydrochloride - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.235 ml | 21.177 ml | 42.355 ml |
| 5 mM | 0.847 ml | 4.235 ml | 8.471 ml |
| 10 mM | 0.424 ml | 2.118 ml | 4.235 ml |
| 5 mM | 0.085 ml | 0.424 ml | 0.847 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: Lazabemide hydrochloride 去供应商网站查看 询盘CAS: 103878-83-7
产地: 上海
规格: L933205
价格: 10mg-640,25mg-1000
库存: 15天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: Lazabemide hydrochloride 去供应商网站查看 询盘CAS: 103878-83-7
产地: 上海
规格: 98%
价格: 5mg 256,25mg 784,100mg 2160
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Lazabemide hydrochloride 98% MedMol 货号：S89980
现货供应
产品名: Lazabemide hydrochloride 去供应商网站查看 询盘CAS: 103878-83-7
产地: 上海
规格: L933205
价格: 10mg-640,25mg-1000
库存: 15天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: Lazabemide hydrochloride 去供应商网站查看 询盘CAS: 103878-83-7
产地: 上海
规格: 98%
价格: 5mg 256,25mg 784,100mg 2160
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Lazabemide hydrochloride 98% MedMol 货号：S89980
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