中文名 | PF 1022A |
英文名 | PF 1022A |
别名 | 化合物 T16497 环(D-2-羟基丙酰基-N-甲基-L-亮氨酰基-3-苯基-D-2-羟基丙酰基-N-甲基-L-亮氨酰基-D-2-羟基丙酰基-N-甲基-L-亮氨酰基-3- 苯基-D-2-羟基丙酰基-N-甲基-L-亮氨酰) |
英文别名 | PF1022A PF 1022A PF-1022A 133413-70-4 Cyclo(D-2-hydroxypropanoyl-N-methyl-L-leucyl-3-phenyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl-3-phenyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl) Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl] |
CAS | 133413-70-4 |
化学式 | C52H76N4O12 |
分子量 | 949.2 |
密度 | 1.070±0.06 g/cm3(Predicted) |
熔点 | 89-92 °C |
沸点 | 1086.6±65.0 °C(Predicted) |
溶解度 | DMSO: ≥ 43 mg/mL |
酸度系数 | -1.09±0.70(Predicted) |
存储条件 | -20℃ |
体外研究 | PF 1022A binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF 1022A binds to GABA receptors, which might contribute to the anthelmintic effect. In vitro, PF 1022A shows low activity on embryonation but significantly inhibits egg hatch (10 and 100 μg/mL), whereas albendazole (10 and 100 μg/mL) reveales statistically significant inhibitions of both embryonation and egg hatch. PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.054 ml | 5.268 ml | 10.535 ml |
5 mM | 0.211 ml | 1.054 ml | 2.107 ml |
10 mM | 0.105 ml | 0.527 ml | 1.054 ml |
5 mM | 0.021 ml | 0.105 ml | 0.211 ml |
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