PS 48
PS 48(PS 48)
CAS: 1180676-32-7
化学式: C17H15ClO2
| 中文名 | PS 48 |
| 英文名 | PS 48 |
| 别名 | 化合物PS 48 PDK1激动剂(PS48) (Z)-5-(4-氯苯基)-3-苯基戊-2-烯酸 |
| 英文别名 | PS48 Ps48 PS 48 PS-48 Ps-48 CS-1466 Ps48 (pdk1 activator) 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid (Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid 2-Pentenoic acid, 5-(4-chlorophenyl)-3-phenyl-, (2Z)- |
| CAS | 1180676-32-7 |
| 化学式 | C17H15ClO2 |
| 分子量 | 286.75 |
| 密度 | 1.225±0.06 g/cm3(Predicted) |
| 熔点 | 114-115℃ |
| 沸点 | 444.1±24.0 °C(Predicted) |
| 溶解度 | DMSO: >20 mg/mL |
| 酸度系数 | 4.55±0.10(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | white to off-white |
| 产品用途 | PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1). |
| WGK Germany | 3 |
| 上游原料 | 4-氯查耳酮 |
| 参考资料 展开查看 | 1. Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.2. Han F, et al. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13(10):1266-1275. |
PS 48 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.487 ml | 17.437 ml | 34.873 ml |
| 5 mM | 0.697 ml | 3.487 ml | 6.975 ml |
| 10 mM | 0.349 ml | 1.744 ml | 3.487 ml |
| 5 mM | 0.07 ml | 0.349 ml | 0.697 ml |
最后更新：2024-01-02 23:10:35
PS 48 - 细胞实验
Human renal mesangial cells (HRMCs) are cultured with 1640 media, containing 10% fetal bovin serum at 37 °C in 5% CO2. Cells are cultured with D-glucose at normal (5.5 mM) or high (25 mM) concentrations in serum-free medium. D-Mannitol (25 mM) is used for a control of osmolality. TP is reconstituted in 0.01% DMSO and freshly diluted with culture medium to 10 ug/L before using. To determine the specific role of PDK1 in TP-potentiated anti-proliferation, 5 μM PS48 (MedChem Express, USA) is applied following the treatment of TP. MTT assay is used to detect cell proliferation. HRMCs are seeded at a density of 1x105/mL into 96-well plates. After 12, 24, 48 and 72 h incubation with different compounds, 20 uL MTT (5 mg/mL) is added to each well. Cells are then cultured for an additional 2 h and subsequently lysed using DMSO (150 uL/well). When the formazan crystals completely dissolve, the optical density (OD) is measured at 570 nm. The arithmetic mean OD of six wells for each group is calculated.
最后更新：2023-08-16 21:32:38
供应商列表
现货供应
产品名: (2Z)-5-(4-Chlorophenyl)-3-Phenyl-2-Pentenoicacid 去供应商网站查看 询盘CAS: 1180676-32-7
产地: 中国上海
包装: 5mg
规格: 99%,PDK1 activator
价格: 1222.00
库存: 5个工作日
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：(2Z)-5-(4-Chlorophenyl)-3-Phenyl-2-Pentenoicacid 英文名:(2Z)-5-(4-Chlorophenyl) 更多
现货供应
产品名: (2Z)-5-(4-Chlorophenyl)-3-Phenyl-2-Pentenoicacid 去供应商网站查看 询盘CAS: 1180676-32-7
产地: 中国上海
包装: 5mg
规格: 99%,PDK1 activator
价格: 1222.00
库存: 5个工作日
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：(2Z)-5-(4-Chlorophenyl)-3-Phenyl-2-Pentenoicacid 英文名:(2Z)-5-(4-Chlorophenyl) 更多
PS 48的上游原料
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