Ro 48-8071富马酸盐

中文名	Ro 48-8071富马酸盐
英文名	Ro 48-8071 fumarate
别名	Ro 48-8071富马酸盐 RO48-8071 富马酸盐化合物RO 48-8071 FUMARATE (4-((6-(烯丙基(甲基)氨基)己基)氧基)-2-氟苯基)(4-溴苯基)甲酮富马酸盐 (4-溴苯基)[2-氟-4-[[6-(甲基-2-丙烯基氨基)己基]氧基]苯基]甲酮富马酸盐
英文别名	CS-1750 RO48-8071 RO 488071 RO-48-8071 Ro 48-8071 fumarate Ro 48-8071 fumarate salt (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone (4-((6-(allyl(methyl)amino)hexyl)oxy)-2-fluorophenyl)(4-bromophenyl)methanone fumarate Ro48-8071
CAS	189197-69-1
化学式	C23H27BrFNO2.C4H4O4
分子量	564.45
熔点	90-92.7°C
溶解度	H2O: 在 ~ 60 °C时> 5mg/ml
存储条件	Inert atmosphere,Store in freezer, under -20°C
外观	固体
颜色	white
体外研究	In HepG2 cells, Ro 48-8071 reduces cholesterol synthesis dose dependently with an IC 50 value of appr 1.5 nM. Ro 48-8071 (10 μM) significantly reduces the viability of PC-3 prostate cancer cells, but not normal prostate cells. Ro 48-8071 (10-30 μM) induces apoptosis of both LNCaP and C4-2 cell lines in a dose-dependent manner. And castration-resistant PC-3 and DU145 cells also demonstrate significant levels of apoptosis following 24-hour treatment with Ro 48-8071. Ro 48-8071 (10-25 μM) reduces AR protein expression in a dose-dependent manner. Ro 48-8071 (0.1-1 μM) increases ERβ protein expression dose-dependently in both hormone-dependent LNCaP and castration-resistant PC-3 cells. Using mammalian cells engineered to express human ERα or ERβ protein, together with an ER-responsive luciferase promoter, Ro 48-8071 dose-dependently inhibits 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC 50 , appr 10 µM), under conditions that are non-toxic to the cells.
体内研究	Ro 48-8071 lowers LDL-C maximally appr 60% at 150 μmol/kg per day, with no further reduction up to 300 μmol/kg per day, leaving HDL-C unchanged at all doses in hamsters. Ro 48-8071 (≥00 μmol/kg per day) increases the amount of MOS in liver of hamsters. Ro 48-8071 (300 μmol/kg per day) remarkedly and significantly reduces VLDL secretion of hamsters. Ro 48-8071 (5 or 20 mg/kg) significantly reduces in vivo tumor growth in mice, without weight loss of the mice. Furthermore, Ro 48-8071 at a concentration of 20 mg/kg, completely eradicates two of the 12 tumors being monitored in the mice in the timeframe tested. Ro 48-8071 (20 mg/day/kg body weight) leads to a rapid and sustained inhibition (>50%) of cholesterol synthesis in the whole small intestine of BALB/c mice. Sterol synthesis is also reduced in the large intestine and stomach.
安全术语	S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。
WGK Germany	3

Ro 48-8071富马酸盐 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.772 ml	8.858 ml	17.717 ml
5 mM	0.354 ml	1.772 ml	3.543 ml
10 mM	0.177 ml	0.886 ml	1.772 ml
5 mM	0.035 ml	0.177 ml	0.354 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

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产品名: Ro 48-8071 fumarate 去供应商网站查看询盘
CAS: 189197-69-1
产地: 北京
包装: 5mg/瓶;
规格: IR2920-5mg
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上海吉至生化科技有限公司

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产品名: (4-((6-(烯丙基(甲基)氨基)己基)氧基)-2-氟苯基)(4-溴苯基)甲酮富马酸盐去供应商网站查看询盘
CAS: 189197-69-1
产地: 中国上海
包装: 10mg
规格: 98%
价格: 473.00
库存: 10个工作日
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产品描述: 中文名：(4-((6-(烯丙基(甲基)氨基)己基)氧基)-2-氟苯基)(4-溴苯基)甲酮富马酸盐英文名:Ro 48-8071 (fumarate) CAS:1 更多

上海麦克林生化科技股份有限公司

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产品名: Ro 48-8071 fumarate 去供应商网站查看询盘
CAS: 189197-69-1
产地: 上海
规格: R880981
价格: 50mg-1361,5mg-359,10mg-545
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上海源叶生物科技有限公司

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产品名: Ro 48-8071 (fumarate) 去供应商网站查看询盘
CAS: 189197-69-1
产地: 上海
规格: 99%
价格: 5mg 240,10mg 384,25mg 752,100mg 1920
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