Streptothricin sulfate
链丝菌素硫酸盐(NOURSEOTHRICIN SULFATE)
CAS: 96736-11-7
化学式: C44H82N18O21S
| 中文名 | 链丝菌素硫酸盐 |
| 英文名 | NOURSEOTHRICIN SULFATE |
| 别名 | 链丝菌素 诺尔丝菌素 链丝菌素硫酸盐 硫酸诺尔丝菌素 诺尔丝菌素硫酸盐 诺尔丝菌素硫酸盐(链丝菌素硫酸盐) NOURSEOTHRICIN SULFATE 诺尔丝菌素 |
| 英文别名 | STREPTOTHRICIN Streptothricin sulfate NOURSEOTHRICIN SULFATE NOURSEOTHRICIN SULPHATE UDVWKDBCMFLRQW-TWRCRAKCSA-N nourseothricin,sulfate(salt) Nourseothricin (streptothricin) sulfate |
| CAS | 96736-11-7 |
| 化学式 | C44H82N18O21S |
| 分子量 | 1231.29488 |
| 溶解度 | H2O: 可溶解200毫克/毫升 |
| 存储条件 | 2-8°C |
| 外观 | 固体 |
| 颜色 | white to light brown |
| 体外研究 | Escherichia coli resistance to neurosporin can be sensitive to resistant strains by eliminating their outer membrane resistance. The polycationic antibiotic, Nourseothricin, represents a mixture of several Streptothricins, mainly D and F. Obviously, although very slowly, it can pass the outer membrane via the porin pores. It has been shown earlier that Nourseothricin is able to generate some kind of channels into the outer membrane through which it can pass the cell wall. On the other hand, there are indications that resistant strains containing a Nourseothricin-inactivating acetyl transferase possess an additional protecting system, namely a reduced penetrability of the outer membrane. |
| 体内研究 | Nourseothricin is preferentially excreted via kidney and signs of nephrotoxicity can be observed after its administration. Renal handling of Nourseothricin is characterized in experiments on renal cortical slices under various experimental conditions. Following administration in vivo the renal tubular transport system for organic anions (p-aminohippurate, PAH) is not influenced by Nourseothricin. There is a high degree of accumulation of Nourseothricin in renal cortical slices. In contrast to PAH accumulation there is no influence of nitrogen atmosphere, simultaneous administration of PAH, probenecid or trishydroxyaminomethane on Nourseothricin accumulation. Age dependent differences in Nourseothricin accumulation does not exist. |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | R22 - 吞食有害。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| RTECS | RD4240000 |
| FLUKA BRAND F CODES | 10 |
Streptothricin sulfate - 介绍
诺尔丝菌素是一种抗菌剂，由土壤细菌的诺尔丝链霉菌产生，属于抗生素中的一种其化学结构为链丝菌素（STs）的亚类。链丝菌素由羧化的葡萄糖胺分子与非典型的氨基酸（streptolidine）和1-7个赖氨酸残基聚合物（ST-F through ST-A and ST-X）组成(Khoklov & Shutova, 1972)。天然提取的诺尔丝菌素是ST-F 和ST-D的混合物。
最后更新：2022-10-16 17:41:59
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