SuberoylBis-hydroxamicAcid

中文名	SuberoylBis-hydroxamicAcid
英文名	SuberoylBis-hydroxamicAcid
别名	软木肟酸次异羟肟酸辛烷-1,8-二氧肟酸 N1,N8-二羟基辛烷二酰胺
英文别名	ODHA SBHA STAT3 (PTYR705) [PTYR705]-STAT3 SUBEROHYDROXAMIC ACID Suberohydroxamic acid SUBERIC BISHYDROXAMATE SuberoylBis-hydroxamicAcid SUBEROYL BISHYDROXAMIC ACID OCTANE-1,8-DIHYDROXAMIC ACID
CAS	38937-66-5
化学式	C8H16N2O4
分子量	204.22
熔点	153-155°C(lit.)
溶解度	H2O: 可溶
存储条件	−20°C
稳定性	吸湿性
外观	冻干粉
颜色	White to Light Beige
MDL号	MFCD00192455
体外研究	Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death.Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells.Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells. Apoptosis Analysis Cell Line: MM-BI and Ist-Mes2 cells Concentration: 10 μM, 20 μM or 50 μM Incubation Time: 24 hours Result: Showed a cooperative effect in cell apoptosis.
体内研究	Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1 (NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth. Animal Model: Nude mice injected with human MTC cells Dosage: 200 mg/kg Administration: Intraperitoneal injection; every 2 days; 12 days Result: Resulted in an average 55% inhibition of tumor growth in SBHA treatment group.
安全术语	S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。
WGK Germany	3

北京索莱宝科技有限公司

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CAS: 38937-66-5
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上海吉至生化科技有限公司

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上海麦克林生化科技股份有限公司

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上海源叶生物科技有限公司

产品名: SuberoylBis-hydroxamicAcid 去供应商网站查看询盘
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