TAS-103(BMS-247615)盐

中文名	TAS-103 (dihydrochloride)
英文名	TAS-103 (dihydrochloride)
别名	TAS-103双盐酸盐 TAS-103(BMS-247615)盐拓扑异构酶I和II抑制剂(TAS-103双盐酸盐) 化合物TAS-103 (DIHYDROCHLORIDE) 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐
英文别名	TAS 103 TAS-103(2HCl) BMS-247615-2HCl TAS-103(BMS-247615) BMS247615 dihydrochloride TAS-103 (dihydrochloride) TAS-103 (dihydrochloride) BMS 247615 dihydrochloride BMS-247615 dihydrochloride 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride
CAS	174634-09-4
化学式	C20H21Cl2N3O2
分子量	406.30564
溶解度	H₂O: 15.3 mg/mL
存储条件	under inert gas (nitrogen or Argon) at 2-8°C
体外研究	TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC 50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC 50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.
体内研究	TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.

TAS-103(BMS-247615)盐 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.461 ml	12.306 ml	24.612 ml
5 mM	0.492 ml	2.461 ml	4.922 ml
10 mM	0.246 ml	1.231 ml	2.461 ml
5 mM	0.049 ml	0.246 ml	0.492 ml

最后更新：2024-01-02 23:10:35

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CAS: 174634-09-4
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产品名: TAS-103 dihydrochloride 去供应商网站查看询盘
CAS: 174634-09-4
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产品名: TAS-103 (dihydrochloride) 去供应商网站查看询盘
CAS: 174634-09-4
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