中文名 | NVP-TNKS656 |
英文名 | NVP-TNKS656 |
别名 | TNKS2抑制剂(NVP-TNKS656) N-环丙基甲基-2-[4-(4-甲氧基苯甲酰基)哌啶-1-基]-N-[(4-氧代-3,5,7,8-四氢-4H-吡喃并[4,3-D]嘧啶-2-基)甲基]乙酰胺 |
英文别名 | TNKS656 CS-1333 TNKS 656 TNKS-656 NVP-TNKS656 NVP-TNKS656 - TNKS 656 1-Piperidineacetamide, N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]- N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide |
CAS | 1419949-20-4 |
EINECS | 604-604-1 |
化学式 | C27H34N4O5 |
分子量 | 494.58 |
密度 | 1.37±0.1 g/cm3(Predicted) |
沸点 | 700.7±70.0 °C(Predicted) |
溶解度 | 溶于DMSO,不溶于水 |
酸度系数 | 6.66±0.10(Predicted) |
存储条件 | Sealed in dry,Store in freezer, under -20°C |
产品用途 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor. |
参考资料 展开查看 | 1: Shultz MD, Cheung AK, Kirby CA, Firestone B, Fan J, Chen CH, Chen Z, Chin DN, Dipietro L, Fazal A, Feng Y, Fortin PD, Gould T, Lagu B, Lei H, Lenoir F, Majumdar D, Ochala E, Palermo MG, Pham L, Pu M, Smith T, Stams T, Tomlinson RC, Tourà BB, Visser M, Wang RM, Waters NJ, Shao W. Identification of NVP-TNKS65 6: The Use of Structure-Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor. J Med Chem. 2013 Aug 22;56(16):6495-511. doi: 10.1021/jm400807n. Epub 2013 Aug 13. PubMed PMID: 23844574。 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.022 ml | 10.11 ml | 20.219 ml |
5 mM | 0.404 ml | 2.022 ml | 4.044 ml |
10 mM | 0.202 ml | 1.011 ml | 2.022 ml |
5 mM | 0.04 ml | 0.202 ml | 0.404 ml |
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