人参皂苷Rk1
人参皂苷Rk1(Ginsenoside Rk1)
CAS: 494753-69-4
化学式: C42H70O12
| 中文名 | 人参皂苷Rk1 |
| 英文名 | Ginsenoside Rk1 |
| 别名 | 人参皂苷Rk1 人参皂苷RK2 |
| 英文别名 | PAN 30 Ginsenoside RK2 Ginsenoside Rk1 β-D-Glucopyranoside, (3β,12β)-12-hydroxydammara-20,24-dien-3-yl 2-O-β-D-glucopyranosyl- 3beta,12beta-Dihydroxydammar-20(21),24-diene-3-O-beta-D-glucopyranosyl(1-2)-beta-D-glucopyranoside |
| CAS | 494753-69-4 |
| 化学式 | C42H70O12 |
| 分子量 | 767 |
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 沸点 | 854.5±65.0 °C(Predicted) |
| 溶解度 | 可溶于水、热甲醇、乙醇等溶剂，不溶于石油醚。 |
| 酸度系数 | 12.85±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 白色无定型粉末 |
| 物化性质 | 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。 |
| MDL号 | MFCD28124355 |
| 体外研究 | Ginsenoside Rk1 (0-40 μM; 6 hours) inhibits MCP-1 and TNF-α mRNA induced by lipopolysaccharide (LPS), expression of IL-1β is inhibited at 40 μM. Ginsenoside Rk1 (0-40 μM; 24 hours) inhibits phosphorylation of JAK2 and STAT3 (Tyr705 and Ser727) in LPS-induced RAW264.7 cells in a dose-dependent manner. Ginsenoside Rk1 (0-160 μM; 48 hours) results in cell viability significant decrease 75.52 ± 2.51% (40 μM), 52.72 ± 2.54% (80 μM), 17.41 ± 2.94% (120 μM)and 12.63 ± 3.24% (160 μM) compared with control. Ginsenoside Rk1 (0-120 μM; 24 hours) increases G0/G1 phase proportion accompanied with S and G2/M phase proportion decrease in MDA-MB-231 cells. Ginsenoside Rk1 (0-120 μM; 24 hours) promotes the percentage of apoptotic cells in a dose-dependent manner, exhibits to reduction of cell number with nucleus fragmentation, condensation and apoptotic body formation. RT-PCR Cell Line: RAW264.7 cells Concentration: 10 μM, 20 μM, 40 μM Incubation Time: 6 hours Result: Inhibited JAK2-dependent STAT3 activation in LPS-activated RAW264.7 cells. Western Blot Analysis Cell Line: RAW264.7 cells Concentration: 10 μM, 20 μM, 40 μM Incubation Time: 6 hours Result: Inhibited JAK2-dependent STAT3 activation in LPS-activated RAW264.7 cells Cell Viability Assay Cell Line: MDA-MB-231 cells Concentration: 0 μM, 40 μM, 80 μM, 120 μM Incubation Time: 48 hours Result: Inhibited MDA-MB-231 cells proliferation in a dose- and time-dependent manner. Cell Cycle Analysis Cell Line: MDA-MB-231 cells Concentration: 0 μM, 40 μM, 80 μM, 120 μM Incubation Time: 24 hours Result: Induced G0/G1 phase arrest. Apoptosis Analysis Cell Line: MDA-MB-231 cells Concentration: 0 μM, 40 μM, 80 μM, 120 μM Incubation Time: 24 hours Result: Induced apoptosis in MDA-MB-231 cells. |
| 参考资料 展开查看 | 1. 高燕霞, 苏娟, 金慧子. 红参高效液相色谱指纹图谱研究[J]. 药学实践杂志, 2016(34):249-251. 2. 董坤园, 于澎, 熊金路,等. 基于高效液相色谱图谱结合化学计量学的红参指纹图谱研究[J]. 食品安全质量检测学报, 2019, 010(021):7316-7321. 3. 邵紫君,李志满,于鹏程,陈建波,李珊珊,孙印石.氨基酸转化三七花中稀有人参皂苷及提取液对脂多糖诱导的RAW264.7细胞活性的影响[J].中草药,2021,52(03):702-710. 4. 张娜,黄鑫,郭云龙,越皓,刘淑莹.基于UPLC-QQQ-MS多指标统计分析研究不同生境人参中皂苷分布[J].特产研究,2020,42(06):48-54. 5. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 6. [IF=5.34] Ji Ye et al."A novel and effective mode-switching triple quadrupole mass spectrometric approach for simultaneous quantification of fifteen ginsenosides in Panax ginseng."Phytomedicine. 2018 May;44:164 7. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 8. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 9. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 10. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 11. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 12. [IF=3.503] Jiajia Dong et al."Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins."Pharm Biol. 2021;59(1):653-661 13. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 14. [IF=3.105] Zhao Yan et al.Protopanaxadiol and Protopanaxatriol Ginsenosides Can Protect Against Aconitine-induced Injury in H9c2 Cells by Maintaining Calcium Homeostasis and Activating the AKT Pathway.J Cardiovasc Pharm. 2021 Nov;78(5):e690-e702 15. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;: 16. [IF=6.576] Zhi-man Li et al."Transformation Mechanism of Rare Ginsenosides in American Ginseng by Different Processing Methods and Antitumour Effects."Frontiers in Nutrition. 2022; 9: 833859 17. [IF=1.885] Guo Na et al."Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis."International Journal of Analytical Ch |
人参皂苷Rk1 - 简介
人参皂苷Rk1是人参中的一种主要有效成分，具有以下性质和用途：
性质：
人参皂苷Rk1属于人参皂苷类化合物，化学结构为二萜型三萜皂苷。它是一种无色结晶性粉末，可溶于水和醇类溶剂。
用途：
人参皂苷Rk1有多种药理活性，被广泛用于中药和保健品中。它具有抗氧化、抗炎、免疫调节、抗癌等多种功能。Rk1可促进血管扩张，并对心血管疾病有一定的保护作用。它还可提高机体的免疫功能、调节神经系统功能、改善记忆力和抑制肿瘤生长。
制法：
人参皂苷Rk1的制法一般是通过高温高压水提取和分离纯化得到的。首先将人参粉末与水进行反应，再通过分离和纯化工艺，如醇沉、柱层析、薄层色谱等方法，去除杂质，得到纯净的人参皂苷Rk1。
安全信息：
人参皂苷Rk1属于天然产物，一般认为具有较好的安全性。经过正规加工和纯化后，其副作用相对较小。但对于个别人群，如孕妇、哺乳期妇女等特殊人群，应在医生的指导下使用。在适当的剂量下，一般不会引起严重的不良反应。如使用过程中出现不适症状，应及时停用并就医。
性质：
人参皂苷Rk1属于人参皂苷类化合物，化学结构为二萜型三萜皂苷。它是一种无色结晶性粉末，可溶于水和醇类溶剂。
用途：
人参皂苷Rk1有多种药理活性，被广泛用于中药和保健品中。它具有抗氧化、抗炎、免疫调节、抗癌等多种功能。Rk1可促进血管扩张，并对心血管疾病有一定的保护作用。它还可提高机体的免疫功能、调节神经系统功能、改善记忆力和抑制肿瘤生长。
制法：
人参皂苷Rk1的制法一般是通过高温高压水提取和分离纯化得到的。首先将人参粉末与水进行反应，再通过分离和纯化工艺，如醇沉、柱层析、薄层色谱等方法，去除杂质，得到纯净的人参皂苷Rk1。
安全信息：
人参皂苷Rk1属于天然产物，一般认为具有较好的安全性。经过正规加工和纯化后，其副作用相对较小。但对于个别人群，如孕妇、哺乳期妇女等特殊人群，应在医生的指导下使用。在适当的剂量下，一般不会引起严重的不良反应。如使用过程中出现不适症状，应及时停用并就医。
最后更新：2024-04-09 20:52:54
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产品名: 人参皂苷Rk1 标准品 去供应商网站查看 询盘CAS: 494753-69-4
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规格: SG9050-10mg,10mg
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库存: 现询
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提供多种规格现货供应
产品名: 人参皂苷Rk1 标准品 去供应商网站查看 询盘CAS: 494753-69-4
产地: 北京
包装: 瓶
规格: SG9050-10mg,10mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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