促甲状腺素释放激素游离酸

中文名	促甲状腺素释放激素游离酸
英文名	TRH
别名	化合物T7407 促甲状腺素释放激素游离酸促甲状腺素释放激素游离酸(普罗瑞林)
英文别名	TRH PYR-HP TRH-OH PYR-HIS-PRO GLP-HIS-PRO PGLU-HIS-PRO PYR-HIS-PRO-OH TRH (FREE ACID)
CAS	24769-58-2
化学式	C16H21N5O5
分子量	363.37
密度	1.461±0.06 g/cm3(Predicted)
沸点	942.1±65.0 °C(Predicted)
酸度系数	3.29±0.20(Predicted)
存储条件	−20°C
体外研究	TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [ 3 H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na + channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na + current amplitude is reduced by 20-50%.
WGK Germany	3

现货供应

产品名: 普罗瑞林杂质4 (普罗瑞林 EP 杂质 D) 去供应商网站查看询盘
CAS: 24769-58-2
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
价格: 电询
库存: 现货
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产品名: THYROTROPIN RELEASING HORMONE 去供应商网站查看询盘
CAS: 24769-58-2
产地: 上海
价格: 2mg 500,5mg 720,10mg 1030,25mg 1580
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