尼罗丝
尼罗红(Nile Red)
CAS: 7385-67-3
化学式: C20H18N2O2
| 中文名 | 尼罗红 |
| 英文名 | Nile Red |
| 别名 | 尼罗丝 尼罗红 尼罗红, 用于荧光分析 |
| 英文别名 | NILE RED Nile Red NILE BLUE A OXAZONE 9-(diethylamino)-5h-benzo[a]phenoxazin-5-on 9-(diethylamino)benzo[a]phenoxazin-5(5H)-one |
| CAS | 7385-67-3 |
| EINECS | 230-966-0 |
| 化学式 | C20H18N2O2 |
| 分子量 | 318.37 |
| InChIKey | VOFUROIFQGPCGE-UHFFFAOYSA-N |
| 密度 | 1.1871 (rough estimate) |
| 熔点 | 203-205 °C(lit.) |
| 沸点 | 457.53°C (rough estimate) |
| 溶解度 | 溶于水 (部分混溶) 和甲醇 (1 mg/ml)。 |
| 折射率 | 1.5700 (estimate) |
| 酸度系数 | 4.08±0.20(Predicted) |
| 存储条件 | 2-8°C |
| 稳定性 | 稳定。与强氧化剂不相容。 |
| 敏感性 | Sensitive to light |
| 外观 | 粉末 |
| 颜色 | Dark red to maroon |
| BRN | 279110 |
| 物化性质 | 生物活性 Nile Red (Nile Blue A oxazone, Phenoxazone 9)是一种十分有效的荧光染料，可在疏水环境下检测细胞内脂质滴 intracellular lipid droplets。Nile Red 可用于细胞内脂质，蛋白质的疏水域和溶酶体磷脂内含体的染色。 |
| MDL号 | MFCD00011639 |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10 |
| 海关编号 | 29349990 |
| 上游原料 | 盐酸 乙醚 异丙醇 镍 3-羟基-N,N-二乙基苯胺 2-羟基-1,4-萘醌 |
| 参考资料 展开查看 | 1. 秋燕 王佑华 李强 刘杰 盛昭园.健脾疏肝降脂方对过度喂养导致的肥胖斑马鱼的影响[J].时珍国医国药 2020 31(03):586-588. 2. 张继芬,张焦,王帆,王帅,王玫,易涛.效应面法优化葛根素纳米晶自稳定Pickering乳液的稳定性[J].中国中药杂志,2017,42(15):2969-2976. 3. 郑锦畅, 康银辉, 魏波,等. 皮质酮促进大鼠成骨细胞内脂质积聚的量效与时效作用的观察[J]. 中国骨质疏松杂志, 2017(09):1126-1131. 4. 徐珍霞, 邓乾春, 董绪燕,等. 超声对亚麻籽蛋白稳定的水包油乳液理化性质的影响[J]. 中国食物与营养, 2019, 025(011):35-40. 5. 李杨,徐清清,韩璐,王迪琼,齐宝坤.添加菊粉条件下的豌豆分离蛋白乳化特性研究[J].农业机械学报,2020,51(07):382-388. 6. 洪泽翰, 吴婉仪, 李璐,等. 不同大分子乳化剂构建番茄红素纳米乳液的体外消化规律比较[J]. 食品科学, 2019, 40(10):9-15. 7. Yanan Kang, Lu Lu, Jinshuai Lan, Yue Ding, Jing Yang, Yong Zhang, Yuan Zhao, Tong Zhang, Rodney J.Y. Ho, Redox-responsive polymeric micelles formed by conjugating gambogic acid with bioreducible poly(amido amine)s for the co-delivery of docetaxel and MMP-9 8. Qin Li, Tingting Zhao, Mei Li, Wenting Li, Bin Yang, Dongran Qin, Kangle Lv, Xian Wang, Lamei Wu, Xiaofeng Wu, Jie Sun, One-step construction of Pickering emulsion via commercial TiO2 nanoparticles for photocatalytic dye degradation, Applied Catalysis B: E 9. Chunfeng Lu, Wenxuan Xu, Jiangjuan Shao, Feng Zhang, Anping Chen, Shizhong Zheng, Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells, International Immunopharmacology, Volume 49, 2 10. Chunfeng Lu, Wenxuan Xu, Shizhong Zheng, Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells, Biomedicine & Pharmacotherapy, Volume 95, 2017, Pages 1-10, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2017.08.0 11. Luyao Zheng, Zhiyuan Zhao, Ye Yang, Yaming Li, Chengxiao Wang, Novel skin permeation enhancers based on amino acid ester ionic liquid: Design and permeation mechanism, International Journal of Pharmaceutics, Volume 576, 2020, 119031, ISSN 0378-5173, https: 12. Zhou, Zijun, et al. Nanoprodrug of retinoic acid-modified paclitaxel. Organic & biomolecular chemistry, 2017, 15.45: 9611-9615. 13. Yin, Xiong, et al. "High‐gravity‐assisted synthesis of aqueous nanodispersions of organic fluorescent dyes for counterfeit labeling." AIChE Journal 65.10 (2019): e16714.https://doi.org/10.1002/aic.16714 14. Wang, Yuxian, et al. "Formulation of pH and temperature dual-responsive Pickering emulsion stabilized by chitosan-based microgel for recyclable biocatalysis." Carbohydrate Polymers 241 (2020): 116373.https://doi.org/10.1016/j.carbpol.2020.116373 15. Qing Pei, Xiuli Hu, Shi Liu, Yang Li, Zhigang Xie, Xiabin Jing, Paclitaxel dimers assembling nanomedicines for treatment of cervix carcinoma, Journal of Controlled Release, Volume 254, 2017, Pages 23-33, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.20 16. [IF=19.503] Qin Li et al."One-step construction of Pickering emulsion via commercial TiO2 nanoparticles for photocatalytic dye degradation."Appl Catal B-Environ. 2019 Jul;249:1 17. [IF=9.776] Qing Pei et al."Paclitaxel dimers assembling nanomedicines for treatment of cervix carcinoma."J Control Release. 2017 May;254:23 18. [IF=6.988] Long Xu et al."Cinnamaldehyde-Based Poly(ester-thioacetal) To Generate Reactive Oxygen Species for Fabricating Reactive Oxygen Species-Responsive Nanoparticles."Biomacromolecules. 2018;19(12):4658–4667 19. [IF=6.638] Yanan Kang et al."Redox-responsive polymeric micelles formed by conjugating gambogic acid with bioreducible poly(amido amine)s for the co-delivery of docetaxel and MMP-9 shRNA."Acta Biomater. 2018 Mar;68:137 20. [IF=5.875] Yuanyuan Li et al."Melatonin loaded with bacterial cellulose nanofiber by Pickering-emulsion solvent evaporation for enhanced dissolution and bioavailability."Int J Pharmaceut. 2019 Mar;559:393 21. [IF=3.876] Zijun Zhou et al."Nanoprodrug of retinoic acid-modified paclitaxel."Org Biomol Chem. 2017 Nov;15(45):9611-9615 22. [IF=3.743] Chunfeng Lu et al."Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells."Biomed Pharmacother. 2017 Nov;95:1 23. [IF=3.361] Chunfeng Lu et al."Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells."Int Immunopharmacol. 2017 Aug;49:203 24. [IF=9.381] Yuxian Wang et al."Formulation of pH and temperature dual-responsive Pickering emulsion stabilized by chitosan-based microgel for recyclable biocatalysis."Carbohyd Polym. 2020 Aug;241:116373 25. [IF=9.147] Amr M. Bakry et al."Myofibrillar protein with κ- or λ-carrageenans as novel shell materials for microencapsulation of tuna oil through complex coacervation."Food Hydrocolloid. 2019 Nov;96:43 26. [IF=9.147] Xianling Wei et al."Fabrication and characterization of emulsions stabilized by tannic acid-wheat starch complexes."Food Hydrocolloid. 2020 Oct;107:105728 27. [IF=9.147] Shulin Zhang et al."Mixed plant-based emulsifiers inhibit the oxidation of proteins and lipids in walnut oil-in-water emulsions: Almond protein isolate-camellia saponin."Food Hydrocolloid. 2020 Dec;109:106136 28. [IF=9.147] Fang Zhang et al."Effect of pH, ionic strength, chitosan deacetylation on the stability and rheological properties of O/W emulsions formulated with chitosan/casein complexes."Food Hydrocolloid. 2021 Feb;111:106211 29. [IF=9.147] Yangyue Ding et al."Effects of endogenous proteins and lipids on structural, thermal, rheological, and pasting properties and digestibility of adlay seed (Coix lacryma-jobi L.) starch."Food Hydrocolloid. 2021 Feb;111:106254 30. [IF=9.147] Yan Tian et al."Effects of protein concentration, pH, and NaCl concentration on the physicochemical, interfacial, and emulsifying properties of β-conglycinin."Food Hydrocolloid. 2021 Sep;118:106784 31. [IF=9.147] Peiyuan Li et al."Preparation and structural characteristics of composite alginate/casein emulsion gels: A microscopy and rheology study."Food Hydrocolloid. 2021 Sep;118:106792 32. [IF=9.147] Xiaofei Li et al."Structural characteristics of gluconic acid δ-lactone induced casein gels as regulated by gellan gum incorporation."Food Hydrocolloid. 2021 Nov;120:106897 33. [IF=9.147] Kai Chen et al."Quinoa protein-gum Arabic complex coacervates as a novel carrier for eugenol: Preparation, characterization and application for minced pork preservation."Food Hydrocolloid. 2021 Nov;120:106915 34. [IF=9.147] Xiao-Min Li et al."Investigation of the fabrication, characterization, protective effect and digestive mechanism of a novel Pickering emulsion gels."Food Hydrocolloid. 2021 Aug;117:106708 35. [IF=8.355] Xingzheng Liu et al."Controllable polymerization of n-butyl cyanoacrylate using a high-gravity rotating packed bed."Chem Eng J. 2020 Jan;379:122400 36. [IF=7.514] Meigui Huang et al."Mixed pretreatment based on pectinase and cellulase accelerates the oil droplet coalescence and oil yield from olive paste."Food Chem. 2022 Feb;369:130915 37. [IF=7.514] Linlin Fan et al."Stable vesicle self-assembled from phospholipid and mannosylerythritol lipid and its application in encapsulating anthocyanins."Food Chem. 2021 May;344:128649 38. [IF=7.182] Chengxiao Wang et al."Dissolvable microneedles based on Panax notoginseng polysaccharide for transdermal drug delivery and skin dendritic cell activation."Carbohyd Polym. 2021 May;:118211 39. [IF=7.053] Yan Tian et al."The role of conformational state of pH-shifted β-conglycinin on the oil/water interfacial properties and emulsifying capacities."Food Hydrocolloid. 2020 Nov;108:105990 40. [IF=6.953] Xi Yang et al."Structuring oil-in-water emulsion by forming egg yolk/alginate complexes: Their potential application in fabricating low-fat mayonnaise-like emulsion gels and redispersible solid emulsions."Int J Biol Macromol. 2020 Mar;147:595 41. [IF=6.953] Huaping Yu et al."Cellulose nanocrystals based clove oil Pickering emulsion for enhanced antibacterial activity."Int J Biol Macromol. 2021 Feb;170:24 42. [IF=5.875] Luyao Zheng et al."Novel skin permeation enhancers based on amino acid ester ionic liquid: Design and permeation mechanism."Int J Pharmaceut. 2020 Feb;576:119031 43. [IF=5.279] Xiaoying Zhang et al."Mechanism of Pentagalloyl Glucose in Alleviating Fat Accumulation in Caenorhabditis elegans."J Agr Food Chem. 2019;67(51):14110–14120 44. [IF=5.268] Long Xu et al."Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery."Colloid Surface B. 2019 Sep;181:252 45. [IF=4.952] Ruihong Wang et al."Changes in egg yolk gelation behaviour and mechanisms during freezing."Lwt Food Sci Technol. 2021 Nov;151:112223 46. [IF=3.366] Huang Lu et al."Identification of Adulterated Extra Virgin Olive Oil by Colorimetric Sensor Array."Food Analytical Methods. 2021 Oct 31 47. [IF=2.262] Jiayi Shi et al."Ultrasonic assisted oil-in-water emulsions stabilized by flaxseed protein isolate: influence of different oils."Journal Of Dispersion Science And Technology. 2021 Feb 11 48. [IF=13.273] Xuefang Hao et al.Biomimetic and responsive nanoparticles loading JQ1 for dual-targeting treatment of vascular restenosis via multiple actions.Chem Eng J. 2021 Nov;:133452 49. [IF=4.35] Bo Zhang et al."Encapsulation of Capsaicin in Whey Protein and OSA-Modified Starch Using Spray-Drying: Physicochemical Properties and Its Stability."Foods. 2022 Jan;11(4):612 50. [IF=13.273] Ruixi Li et al."Monitoring inflammation-cancer progression by cell viscosity, polarity and leucine aminopeptidase using multicolor fluorescent probe."Chem Eng J. 2022 May;435:135043 51. [IF=4.952] Yue Dong et al."Oleogel-based Pickering emulsions stabilized by ovotransferrin–carboxymethyl chitosan nanoparticles for delivery of curcumin."Lwt Food Sci Technol. 2022 Mar;157:113121 52. [IF=4.35] Yifan Lu et al."Sodium Caseinate and Acetylated Mung Bean Starch for the Encapsulation of Lutein: Enhanced Solubility and Stability of Lutein."Foods. 2022 Jan;11(1):65 53. [IF=5.396] Dandan Shan et al."Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin."Food Funct. 2021 Dec;: 54. [IF=7.79] Hui Jian et al."Zeolitic imidazolate framework-based nanoparticles for the cascade enhancement of cancer chemodynamic therapy by targeting glutamine metabolism."Nanoscale. 2022 May;: 55. [IF=3.495] Yong Pei et al."Two typical acyl-CoA-binding proteins (ACBPs) are required for the asexual development and virulence of Phytophthora sojae."FUNGAL GENETICS AND BIOLOGY. 2022 May;:103695 56. [IF=7.514] Chun-Min Ma et al."Impact of covalent grafting of two flavonols (kaemperol and quercetin) to caseinate on in vitro digestibility and emulsifying properties of the caseinate-flavonol grafts."FOOD CHEMISTRY. 2022 Oct;390:133210 57. [IF=9.147] Yangyang Jia et al."Emulsification mechanism of persimmon pectin with promising emulsification capability and stability."Food Hydrocolloid. 2022 Apr;:107727 58. [IF=4.35] Xiuyun Zhang et al."Fabrication and Characterization of Whey Protein—Citrate Mung Bean Starch—Capsaicin Microcapsules by Spray Drying with Improved Stability and Solubility."Foods. 2022 Jan;11(7):1049 59. [IF=3.639] Yuanda Sun et al."Stability and digestibility of encapsulated lycopene in different emulsion systems stabilized by acid-modified soybean lipophilic protein."JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE |
尼罗丝 - 性质
尼罗红是一种具有鲜艳红色的有机染料，化学名称为对二氨基偶氮苯硫酸钠。以下是尼罗红的一些性质：
1. 颜色和溶解度：尼罗红呈现鲜红色，是一种易溶于水的染料。
2. pH响应：尼罗红具有酸碱敏感性，其溶液的颜色会随着pH的变化而改变。在弱酸性条件下呈黄色，中性下呈红色，碱性条件下呈蓝色。
3. 稳定性：尼罗红对光、热和湿度相对稳定。但在强酸和强碱条件下，尼罗红可能会分解或变色。
4. 应用：尼罗红常用于生化实验中作为染料或者指示剂。它可以用于显微镜下观察细胞核和染色体的结构，也可以用于蛋白质凝胶电泳中的染色。
1. 颜色和溶解度：尼罗红呈现鲜红色，是一种易溶于水的染料。
2. pH响应：尼罗红具有酸碱敏感性，其溶液的颜色会随着pH的变化而改变。在弱酸性条件下呈黄色，中性下呈红色，碱性条件下呈蓝色。
3. 稳定性：尼罗红对光、热和湿度相对稳定。但在强酸和强碱条件下，尼罗红可能会分解或变色。
4. 应用：尼罗红常用于生化实验中作为染料或者指示剂。它可以用于显微镜下观察细胞核和染色体的结构，也可以用于蛋白质凝胶电泳中的染色。
最后更新：2024-04-10 22:29:15
尼罗丝 - 用途与合成方法
尼罗红（Nile Red）是一种有机染料，常用于化学分析、生物荧光标记和材料科学研究中。以下是尼罗红的主要用途和合成方法的介绍：
用途：
1. 化学分析：尼罗红可用作指示剂和荧光探针，用于检测某些物质的存在、识别溶液中的离子和分析有机化合物。
2. 生物荧光标记：尼罗红具有很强的荧光特性，它被广泛用于生物荧光显微镜、流式细胞术和免疫组化技术等生物学研究中，用于标记和跟踪生物分子和细胞。
3. 材料科学研究：尼罗红可以作为染料、表面活性剂、光敏材料等应用于材料科学领域，例如超分子组装、液晶材料、电致变色等。
合成方法：
尼罗红的合成方法较为简单，其中一种常用的方法如下：
将苯胺与硝酸反应生成硝基苯胺（甲），然后用NaOH与邻硝基苯胺（甲）反应得到尼罗红。具体步骤如下：
1. 将苯胺加入含硫酸的冷混合酸中，与硝酸反应生成硝基苯胺（甲）。
2. 将硝基苯胺（甲）与过量的氢氧化钠反应，在碱性条件下形成尼罗红。
尼罗红的合成方法还有其他变种，但这是其中一种常用且较简便的方法。尼罗红的产率和纯度可以通过反应条件的调节来进行优化。
用途：
1. 化学分析：尼罗红可用作指示剂和荧光探针，用于检测某些物质的存在、识别溶液中的离子和分析有机化合物。
2. 生物荧光标记：尼罗红具有很强的荧光特性，它被广泛用于生物荧光显微镜、流式细胞术和免疫组化技术等生物学研究中，用于标记和跟踪生物分子和细胞。
3. 材料科学研究：尼罗红可以作为染料、表面活性剂、光敏材料等应用于材料科学领域，例如超分子组装、液晶材料、电致变色等。
合成方法：
尼罗红的合成方法较为简单，其中一种常用的方法如下：
将苯胺与硝酸反应生成硝基苯胺（甲），然后用NaOH与邻硝基苯胺（甲）反应得到尼罗红。具体步骤如下：
1. 将苯胺加入含硫酸的冷混合酸中，与硝酸反应生成硝基苯胺（甲）。
2. 将硝基苯胺（甲）与过量的氢氧化钠反应，在碱性条件下形成尼罗红。
尼罗红的合成方法还有其他变种，但这是其中一种常用且较简便的方法。尼罗红的产率和纯度可以通过反应条件的调节来进行优化。
最后更新：2024-04-10 22:29:15
供应商列表
现货供应
产品名: NileRed尼罗红 去供应商网站查看 询盘CAS: 7385-67-3
产地: 北京
包装: 瓶
规格: N8440-100mg,100mg,IN0170-D-1ml,10mM*1ml(inDMSO),IN0170-5mg,5mg,IN0170-10mg,10mg,IN0171-5mg,5mg,IN017
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
现货供应
产品名: NileRed尼罗红 去供应商网站查看 询盘CAS: 7385-67-3
产地: 北京
包装: 瓶
规格: N8440-100mg,100mg,IN0170-D-1ml,10mM*1ml(inDMSO),IN0170-5mg,5mg,IN0170-10mg,10mg,IN0171-5mg,5mg,IN017
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
尼罗丝的上游原料
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！