帕罗伐汀_化工百科

中文名	Palovarotene
英文名	Palovarotene
别名	帕罗伐汀 4-[(1E)-2-[5,6,7,8-四氢-5,5,8,8-四甲基-3-(1H-吡唑-1-基甲基)-2-萘基]乙烯基]苯甲酸
英文别名	R 667 Ro 3300074 RO 3300074 Palovarotene palovarotene Unii-28K6I5m16g Palovarotene(R 667) (E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid 4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid
CAS	410528-02-8
EINECS	200-258-5
化学式	C27H30N2O2
分子量	414.54
密度	1.11
熔点	249-252°C
沸点	592.3±50.0 °C(Predicted)
溶解度	DMSO (微溶)，乙酸乙酯 (微溶，加热)，甲醇 (微溶，加热)
酸度系数	4.26±0.10(Predicted)
存储条件	Refrigerator
外观	固体
颜色	White to Off-White
体内研究	Palovarotene suppresses post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation. Palovarotene inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Palovarotene is given orally for 14 days at 1 mg/kg/day starting on post-operative day (POD) 1 or POD-5, and HO amount, wound dehiscence and related processes are monitored for up to 84 days post injury. Compared to vehicle-control animals, Palovarotene significantly decreases HO by 50 to 60% regardless of when the treatment started and if infection is present. Starting from day 1 of injury, half of the Acvr1 cR206H/+ mice are treated with Palovarotene by daily gavage for 14 days and the other half received vehicle as control. Analysis by mCT and 3D image reconstruction at day 14 shows that large HO tissue masses have formed in the targeted leg of Acvr1 cR206H/+ mutant mice receiving vehicle, but HO formation is greatly diminished in Palovarotene-treated companions by more than 80% based on bone volume/total volume quantification.

帕罗伐汀 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.412 ml	12.062 ml	24.123 ml
5 mM	0.482 ml	2.412 ml	4.825 ml
10 mM	0.241 ml	1.206 ml	2.412 ml
5 mM	0.048 ml	0.241 ml	0.482 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

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产品名: 帕罗伐汀去供应商网站查看询盘
CAS: 410528-02-8
产地: 北京
包装: 1mg(瓶)
规格: IPA10830-1mg
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上海吉至生化科技有限公司

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产品名: Palovarotene 去供应商网站查看询盘
CAS: 410528-02-8
产地: 中国上海
包装: 10mg
规格: 99%
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产品描述: 中文名：Palovarotene 英文名:Palovarotene CAS:410528-02-8 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

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产品名: Palovarotene 去供应商网站查看询盘
CAS: 410528-02-8
产地: 上海
规格: P879124
价格: 5mg-1733,10mg-2816
库存: 7天内发货
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上海源叶生物科技有限公司

产品名: Palovarotene 去供应商网站查看询盘
CAS: 410528-02-8
产地: 上海
规格: 98%
价格: 5mg 1600,10mg 2600
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