PX-478 由BOC Sciences提供
联系方式
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| 公司名 | BOC Sciences |
| 联系人 | Linna Green |
| 电 话 | +16314854226 |
| 手 机 | +16314854226 |
| 电子邮件 | info@bocsci.com |
| 网 址 | https://www.bocsci.com/ |
| 地 区 | 其他 |
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向其他PX-478供应商询盘
品名: PX-478 2HCl
CAS: 685898-44-6
规格: P872920
价格: 5mg-986,1ml-805
最后更新: 2024-10-16 22:52:26
CAS: 685898-44-6
规格: P872920
价格: 5mg-986,1ml-805
最后更新: 2024-10-16 22:52:26
品名: (S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
CAS: 685898-44-6
规格: YS107207-5mg
包装: 瓶
价格: 电话、微信、QQ、邮件
产地: 北京
最后更新: 2025-05-22 14:59:52
CAS: 685898-44-6
规格: YS107207-5mg
包装: 瓶
价格: 电话、微信、QQ、邮件
产地: 北京
最后更新: 2025-05-22 14:59:52
品名: L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
CAS: 685898-44-6
包装: 5mg
价格: 面议、电联、微信、QQ
产地: 中国上海
最后更新: 2025-01-22 19:13:57
CAS: 685898-44-6
包装: 5mg
价格: 面议、电联、微信、QQ
产地: 中国上海
最后更新: 2025-01-22 19:13:57
品名: PX-478
CAS: 685898-44-6
规格: HY-10231
包装: 5 mg;10 mg;50 mg
产地: 美国
最后更新: 2025-05-21 16:50:25
CAS: 685898-44-6
规格: HY-10231
包装: 5 mg;10 mg;50 mg
产地: 美国
最后更新: 2025-05-21 16:50:25
PX-478的基本信息
| 中文名 | PX-478 |
| 英文名 | (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride |
| 别名 | 化合物PX-478 2HCL;(S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐 |
| CAS | 685898-44-6 |
| EINECS | |
| 化学式 | C13H19Cl3N2O3 |
| 分子量 | 357.66 |
| inchi | |
| 包装信息 | 100 mg |
| 价格 | $519 |
| 产品描述 | PX-478 PX-478 is an HIF-1alpha inhibitor and an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of this agent is independent of the tumor suppressor genes VHL and p53 and may be related to derangements in glucose uptake and metabolism due to inhibition of glucose transporter-1 (Glut-1). PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity. It is rapidly absorbed following oral and i.p. administration and gives excellent Cmax and AUC via these routes. |
| 产品链接 | https://www.bocsci.com/product/px-478-dihydrochloride-cas-685898-44-6-459441.html |
| 更新日期 | 2025-04-30 11:27:47 |