151619-90-8
益母草提取物
CAS: 151619-90-8
Molecular Formula: C14H20O3
151619-90-8 - Names and Identifiers
| Name | 益母草提取物 |
| Synonyms | Herba Leonuri P.E. Motherwort Herb P.E. LeonurusheterophyllusP.E Leonurus japonicus extract 1-Butanol, 2-methyl-4-(phenylmethoxy)-, acetate, (S)- (9CI) |
| CAS | 151619-90-8 |
151619-90-8 - Physico-chemical Properties
| Molecular Formula | C14H20O3 |
| Molar Mass | 236.31 |
| Density | 1.020±0.06 g/cm3(Predicted) |
| Boling Point | 317.4±25.0 °C(Predicted) |
| Storage Condition | Room Temprature |
151619-90-8 - Reference Information
| Plant Source: | motherwort |
| plant extract | Herba leonuri extract is obtained from the Labiatae plant Herba leonuri leonrus Houtt. A brown active substance extracted from fresh or dried aerial parts, in which stachydrine hydrochloride is the main active ingredient. [Place of origin] motherwort, also known as motherwort, Xiwei, wild Gastrodia elata, and ground motherwort, was born in the slope grassland, field Ridge, side of the road, near the stream and other places below 3400m in altitude, especially in the Yang, distributed all over China. Mainly produced in Henan, Anhui, Sichuan, Jiangsu, Zhejiang, Guangdong, Guangxi, Hebei also produced. Fresh products were harvested from spring seedling stage to early flowering stage in early summer. Dry products were harvested and dried in summer when stems and leaves were rich and flowers were not opened or first opened. [plant morphology] motherwort is an annual or biennial herb, which has the main root of dense fibrous root. Fresh products were harvested from spring seedling stage to early flowering stage in early summer. Dry products were harvested and dried in summer when stems and leaves were rich and flowers were not opened or first opened. Fresh leonurus heterophyllus: no stem at seedling stage, with round and heart-shaped basal leaves, with 5-9 shallow fissures on the margin and 2-3 blunt teeth on each lobe. The stem at the prophase of flowering was square-columnar, multi-branched in the upper part, concave into longitudinal grooves on all sides, 30-0.2 in length, 0.5cm-in diameter; The surface was cyan; Fresh and tender in firmness, pith in the middle of the section. The leaves were alternately opposite, with stems; The leaves were Cyan in color, fresh and tender in firmness, with juice; The lower cauline leaves were palpated with 3 lobes, and the upper leaves were pinnately divided into 3 pieces, lobes entire or with few serrations. Slight gas, slightly bitter taste. FIG. 1 shows Motherwort. |
| Main components | the whole plant contains about 0.05% of Leonurine (it contains trace amount at the beginning of flower, gradually increased at the flowering stage), stachydrine, Rutin, Fumaric acid, Herba leonuri, 4-guanidylbutanol, 4-guanidylbutyric acid, arginine, Ampelopsis extract, stigmasterol and sitosterol. 5 kinds of crystalline substances: motherwort A, motherwort B and motherwort A, B and C. The flowers contained motherwort alkaloid. |
| medicinal property | bitter, slightly cold. Liver, kidney and pericardium. |
| efficacy | motherwort contains a variety of trace elements. Selenium has the function of enhancing the vitality of immune cells, alleviating the occurrence of atherosclerosis and improving the body's defense function system. Manganese can resist oxidation, aging, fatigue and inhibit the proliferation of cancer cells. Therefore, motherwort can benefit the beauty, anti-aging and anti-aging. The motherwort aqueous extract (1:4) was used to treat dermatopathogenic fungi such as xanthophyton Xilan, wool-like small Bacillus, epidermal ringworm, and Nocardia astrocystis in vitro, all have different degrees of inhibition. In addition, motherwort extract can also be used for anti-inflammatory, whitening, irregular menstruation, dysmenorrhea and amenorrhea, lochia, postpartum blood stasis Abdominal Pain, nephritis edema, urine adverse, sore, swelling, bruises damage. |
| effect on cardiovascular system | (1) anti-atherosclerosis (AS) effect: motherwort mixture (1:1 of motherwort and Hawthorn composition) has the control and removal of lipid peroxidation (LPO), improve the activity of superoxide dismutase (SDO), after administration of whether in the blood, or heart, in brain tissue, LPO decreased significantly and SDO activity increased. The pathological sections of coronary artery showed that the cells in the inner wall of the coronary artery in the control group were exfoliated, the elastic fibers were broken, absent and damaged, the blood cells were infiltrated, and the artery was obviously diseased. This product has anti-AS effect. With motherwort juice daily 1 g/kg mixed feed, determination of animal blood, heart, brain tissue histamine content changes, anti-AS effect and inhibit the abnormal metabolism of histamine, more conducive to the prevention and treatment of vascular lesions. (2) antithrombotic effect: Herba leonuri has obvious inhibitory effect on all stages of experimental thrombosis. Herba leonuri and its preparations can reduce the content of fibrinogen in blood, shorten the dissolution time of euglobulin, and prolong the partial coagulation time of prothrombin and kaolin. Antibody external thrombosis, anti-platelet aggregation, so that the whole blood viscosity and reduction viscosity is very significantly reduced, the clinical trial has a good effect. Studies have shown that motherwort by inhibiting platelet function, inhibition of internal and external coagulation system function and promote fibrinolytic activity three aspects of inhibition of thrombosis, this product is a promising blood circulation medicine. (3) the role of the Heart: motherwort ethanol extract on the rabbit heart in the body has a mild Excitatory effect, this product can significantly increase coronary and myocardial blood flow, direct expansion of peripheral blood vessels, slow down the heart rate, decreased cardiac output and left ventricular work. The active ingredient is stachydrine. Herba leonuri and its preparations have improved and protective effects on myocardial ultrastructure during myocardial ischemia induced by pituitrin and isoproterenol and myocardial infarction induced by ligation of anterior descending branch of coronary artery in dogs. |
| pharmacological action | 1. Effect of exciting uterus motherwort decoction, water and ethanol extract to rabbits, cats, guinea pigs and other animals by perfusion or intravenous injection, in vitro, in the body uterus and uterine fistula were excited. Its role is similar to the posterior pituitary hormone, whether it has been pregnant or not, it can significantly enhance the uterine contraction, and the duration is long. The decoction is more effective than the tincture, and the active ingredients mainly exist in the leaves. Motherwort can also make the small amplitude of the uterus irregular, spontaneous contraction into a large amplitude of the regular contraction, its effect is dose-related. 2. Antispasmodic and blood stasis removing effect motherwort oral liquid and motherwort granule are composed of motherwort, Ligusticum Chuanxiong, Angelica sinensis and radix aucklandiae. Both 28g/kg and 3.5g/kg administration can significantly antagonize the uterine spasm induced by oxytocin in rats, and reduce the tension. But the effect of oral liquid is stronger than that of granule, and there is significant difference in large dose. This may lie in the oral liquid containing less impurities, high bioavailability, easy to reach the role of the site of the relevant. Herba leonuri oral liquid and granule can significantly inhibit the acute inflammation of mouse auricle induced by croton oil and have better anti-inflammatory effect. Two doses of oral liquid and granule can significantly improve microcirculation and antagonize the microcirculation disturbance induced by pituitrin. And can significantly reduce the animal plasma thromboxane B2 levels. 3. Diuretic effect on intravenous injection of anesthesia rabbits, motherwort alkali has significant diuretic effect. The rabbits were anesthetized by intravenous injection of 1 mg/kg, and after a few minutes, the urine volume increased by 2 to 3 times. 4. Hypotensive effect motherwort water extract, seed water extract, ethanol extract, total alkaloids of motherwort, and decoction of flowers all have the effect of lowering blood pressure in anesthetized animals by intravenous injection, and the duration of blood pressure reduction is short. Antibacterial effect motherwort herb decoction had inhibitory effect on E. Coli and Shigella dysenteriae by plate test. The 1:4 aqueous extract of leonurus heterophyllus was diluted in test tube to inhibit dermatophytes such as xanthophyton Xu, small wool-like Bacillus sp., epidermal ringworm, and stellate novocapsula sp. 6. Stimulating respiration motherwort alkali can stimulate the respiration of anesthetized cats and rabbits, which is not affected by cutting off the vagus nerve. Therefore, it is speculated that the respiratory center is directly excited to increase the respiratory amplitude, frequency increased. |
| analytical method | a common analytical method is liquid chromatography. FIG. 2 is a liquid chromatogram of fresh motherwort extract. |
| toxic side effects | motherwort has very low toxicity. LD50 (572.2±37.2) mg/kg, motherwort extract can cause abortion in pregnant rabbits, but had no effect on body temperature, respiration and heart rate. If you take more than 30g, you can poisoning within 4~6 hours. Symptoms: general weakness, soreness, inability to move lower limbs, chest tightness; Heavy sweating, and collapse. |
Last Update：2024-04-09 20:52:54
