4-(Methoxymethyl)pyridine
4-(methoxymethyl)pyridine
CAS: 20027-70-7
Molecular Formula: C7H9NO
4-(Methoxymethyl)pyridine - Names and Identifiers
| Name | 4-(methoxymethyl)pyridine |
| CAS | 20027-70-7 |
4-(Methoxymethyl)pyridine - Physico-chemical Properties
| Molecular Formula | C7H9NO |
| Molar Mass | 123.15246 |
4-(Methoxymethyl)pyridine - Introduction
4-(methoxy methyl)pyridine is an organic compound with the chemical formula C8H11NO and a molecular weight of 137.18g/mol.
Its properties are as follows:
1. Appearance: It is a colorless liquid or solid.
2. Solubility: Soluble in many organic solvents, such as methanol, ethanol and ethers.
3. Melting Point: about 60-62 ℃.
4. Boiling point: About 215-216 ℃.
4-(methoxy methyl)pyridine has many applications in organic synthesis:
1. As a solvent: Because of its good solubility, it is often used as a solvent for organic synthesis reactions.
2. Reaction intermediate: It can be used as an intermediate for various organic reactions, such as the synthesis of alkali metal methanol complexes, condensation reactions and substitution reactions.
3. Acid catalyst: It can be used for the synthesis of ketones and ethers catalyzed by sulfuric acid.
Preparation method of 4-(methoxy methyl)pyridine:
1. Methylation: pyridine is reacted with methanol, and an acidic catalyst, such as sulfuric acid or hydrogen chloride, is added. The product can be obtained by reacting for several hours at an appropriate temperature and pressure.
2. Condensation reaction of aldol and Amine: 4-methyl carbaldehyde reacts with methanol to generate oxymethide, and then reacts with pyridine to obtain the target product.
When using 4-(methoxymethyl)pyridine, pay attention to its safety:
1. Contact with skin: may cause irritation and allergic reactions, should be washed with plenty of water immediately after contact, if not adapt to the immediate medical treatment.
2. Inhalation: Prolonged exposure to high concentrations may cause irritation to the respiratory system. It should be used in a well-ventilated place to avoid inhaling gas or vapor. If maladjustment occurs, seek medical attention immediately.
3. Ingestion: may cause damage, such as accidental ingestion should immediately seek medical attention.
Its properties are as follows:
1. Appearance: It is a colorless liquid or solid.
2. Solubility: Soluble in many organic solvents, such as methanol, ethanol and ethers.
3. Melting Point: about 60-62 ℃.
4. Boiling point: About 215-216 ℃.
4-(methoxy methyl)pyridine has many applications in organic synthesis:
1. As a solvent: Because of its good solubility, it is often used as a solvent for organic synthesis reactions.
2. Reaction intermediate: It can be used as an intermediate for various organic reactions, such as the synthesis of alkali metal methanol complexes, condensation reactions and substitution reactions.
3. Acid catalyst: It can be used for the synthesis of ketones and ethers catalyzed by sulfuric acid.
Preparation method of 4-(methoxy methyl)pyridine:
1. Methylation: pyridine is reacted with methanol, and an acidic catalyst, such as sulfuric acid or hydrogen chloride, is added. The product can be obtained by reacting for several hours at an appropriate temperature and pressure.
2. Condensation reaction of aldol and Amine: 4-methyl carbaldehyde reacts with methanol to generate oxymethide, and then reacts with pyridine to obtain the target product.
When using 4-(methoxymethyl)pyridine, pay attention to its safety:
1. Contact with skin: may cause irritation and allergic reactions, should be washed with plenty of water immediately after contact, if not adapt to the immediate medical treatment.
2. Inhalation: Prolonged exposure to high concentrations may cause irritation to the respiratory system. It should be used in a well-ventilated place to avoid inhaling gas or vapor. If maladjustment occurs, seek medical attention immediately.
3. Ingestion: may cause damage, such as accidental ingestion should immediately seek medical attention.
Last Update：2024-04-10 22:29:15
