Name | 4-Iodobenzaldehyde |
Synonyms | NSC 84301 4-IODOBENZALDEHYDE 4-Iodobenzaldehyde P-IODOBENZALDEHYDE Benzaldehyde, 4-iodo- Benzaldehyde of iodine |
CAS | 15164-44-0 |
EINECS | 627-186-1 |
InChI | InChI=1/C7H5IO/c8-7-3-1-6(5-9)2-4-7/h1-5H |
InChIKey | NIEBHDXUIJSHSL-UHFFFAOYSA-N |
Molecular Formula | C7H5IO |
Molar Mass | 232.02 |
Density | 1.8576 (estimate) |
Melting Point | 78-82 °C (lit.) |
Boling Point | 265°C(lit.) |
Flash Point | 114°C |
Water Solubility | Insoluble in water. |
Vapor Presure | 0.0095mmHg at 25°C |
Appearance | Solid |
Color | Yellow |
BRN | 636101 |
Storage Condition | 2-8°C |
Sensitive | Air & Light Sensitive |
Refractive Index | 1.668 |
MDL | MFCD00039576 |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
HS Code | 29130000 |
Hazard Class | IRRITANT, AIR SENSIT |
introduction | 4-iodobenzaldehyde is yellow crystal, its melting point is 78-82°C (lit.), boiling point is 265°C(lit.), density is 1.8576 (estimate). Generally stored at 2-8°C. As a kind of very important organic synthesis intermediates, 4-iodobenzaldehyde has shown important application value and broad development prospects in the field of organic synthesis due to its unique chemical structure. |
application | 4-iodobenzaldehyde has been widely used in the construction of compound skeletons with complex structures, the synthesis of pharmaceutical intermediates, the synthesis of natural products and the development of fluorescent materials. With the rapid development of organic synthesis chemistry, new catalysts, new synthesis methods and new synthesis processes are constantly emerging. 4-iodobenzaldehyde derivatives will be more used in the synthesis of complex compounds, and then produce more compounds with novel structures, which will play a positive role in the development of organic synthesis chemistry, pharmaceutical chemistry, natural product chemistry, material chemistry and other fields. |
synthesis method | the mixture of 10.0 g p-bromobenzaldehyde (54 mmol), 81.1g KI(488 mmol,9.0 equivalent), 31.7g CuI(166 mmol,3.1 equivalent) and 150 ml newly distilled DMI was placed in a 500 ml three-neck flask. The mixture was purged with N2 and heated with vigorous stirring at 200°C for 6 h. After cooling to room temperature, add salt water and ice. The reaction vessel was placed in an ice bath for several hours and then the precipitated inorganic salts were removed by filtration. The filtrate was extracted with ether, the extract was combined and washed with salt water. Remove the solvent under reduced pressure. 9.20g 2c(73%). All spectral data are consistent with the reported values. 1H NMR(CDCl3)δ:9.96(1H,s), 7.92(2H,d,J = 8.4Hz), 7.91(2H,s) and 7.59(2H,d,J = 8.4 Hz)ppm. |