| Name | Acetofenate |
| Synonyms | Acetofenate Bayer 78257 acetophenate 1,1,1-Trichloro-2(3,4-dichlorophenyl)ethanol acetate Benzenemethanol, 3,4-dichloro-2-(trichloromethyl)-, 1-acetate |
| CAS | 51366-25-7 |
| Molecular Formula | C10H7Cl5O2 |
| Molar Mass | 336.43 |
| Density | 1.547±0.06 g/cm3(Predicted) |
| Boling Point | 353.8±37.0 °C(Predicted) |
| Physical and Chemical Properties | The pure chemical product is white crystal. M. p.84.5 ℃(83.7 ℃), vapor pressure 1.5 × 10-9Pa (20 ℃). Solubility at 20 ℃: toluene> 60%, dichloromethane> 60%, cyclohexanone> 60%, isopropanol <1%, and soluble in organic solvents such as acetone, benzene, toluene, xylene, hot methanol, ethanol, etc., with 0.005% solubility in water. It is more stable in neutral and weakly acidic media and decomposes with alkali. |
| Use | Use of health medicine, for the prevention and control of flies, mosquitoes, moth and other pests |
Toxicity
acute oral LD50>10000mg/kg for male and female rats, 2500mg/kg for male and female mice, 1000mg/kg for male dogs and 2500mg/kg for male rabbits. Acute percutaneous LD50>1000mg/kg in male rats (3600mg/kg in rats). Acute inhalation of LC50>516mg/ m3(4h) in male rats and> 567mg/ m3(4h) in male mice. Rats were fed for 3 months at a non-effective dose of 1000mg/kg. Animal experiments have no teratogenic or mutagenic effects. Fish poison LC50 is 1.52mg/L.
use
1. Insecticides that have both contact and fumigation effects and prevent sanitary pests have good effects on Diptera flies, mosquitoes and lice, and are low in toxicity to mammals, easy to degrade, and have no cumulative effect. For example, 10mL of 20% emulsifiable concentrate and 190mL of water are used for indoor mosquito control, 0.4mL/m3 is sprayed, and 2g of active ingredient/m2 is used for indoor wall retention spraying, which is effective for more than 25d. 3%o powder was used to control head lice, and all head lice died after 1 week. In addition, mother powder can be used to make mosquito-repellent incense; wettable powder can be used for pigsty and cowshed treatment. It can also be made into sprays, aerosols, electric fumigation tablets, aerosols, etc.
2, mainly used to control mosquitoes and flies. Retention spraying can prevent mosquitoes and flies for a month. 0.5% concentration is effective in preventing larvae in puddles. Prevent bedbugs in dormitories and hotels, add 25kg of water to the 25% suspension, and spray 50-100 beds.
production method
1. put o-dichlorobenzene into a synthetic pot, start stirring, cool with -10 ℃ brine, add aluminum trichloride and trichloroacetaldehyde, and maintain the reaction at 10-20 ℃ for 3.5h. Add acetic anhydride (or acetic acid, etc.) to cool the material to 0 ℃, and maintain the reaction at 4-8 ℃ for 1h. The obtained 7504 synthesis liquid is distilled under reduced pressure to recover o-dichlorobenzene. The distilled residue is put into the crystallizer. Add alcohol, stir well, cool, crystallize completely, filter to obtain 7504 product. The filtrate can collect alcohol and o-dichlorobenzene. 85% yield. Ingredients ratio (mole): o-dichlorobenzene: trichloroacetaldehyde: aluminum trichloride: acetic anhydride = 7:1:1.18: 1 raw material consumption quota (100% trichloroinsecticidal ester): o-dichlorobenzene (98%)787kg/t, trichloroacetaldehyde (97%)638kg/t, aluminum trichloride (99%)606kg/t.
2,2,2, 2-trichloro-1-(3, 4-dichlorophenyl) ethanol complex preparation in the presence of aluminum trichloride, by o-dichlorobenzene and trichloroacetaldehyde reaction, temperature 10~20 ℃, time 3.8h, ratio of o-dichlorobenzene: trichloroacetaldehyde: aluminum trichloride = 7:1:1.1, 2,2-trichlor, 4-Dichlorophenyl) ethanol complex.
Synthesis of trichloroinsecticidal ester In the presence of sulfuric acid and phosphorus trichloride, the 2,2, 2-trichloro-1-(3, 4-dichlorophenyl) ethanol complex synthesized in the previous reaction Directly react with acetic acid (acetic anhydride) to synthesize trichloroinsecticidal ester. The reaction temperature is 4~8 ℃, the reaction time is 1.5h, the raw material ratio is trichloroacetaldehyde: acetic anhydride = 1:0.9 (acetic anhydride method), trichloroacetaldehyde: acetic acid: phosphorus trichloride: sulfuric acid = 1:1.5:0.58:0.51 (acetic acid method) (average mol)
the average yield of the intermediate test is 82.7% under similar process conditions, and the literature report can reach 92%.