Dimethylcarbamoyl chloride
dimethylcarbamoyl chloride
CAS: 79-44-7
Molecular Formula: C3H6ClNO
Dimethylcarbamoyl chloride - Names and Identifiers
Dimethylcarbamoyl chloride - Physico-chemical Properties
| Molecular Formula | C3H6ClNO |
| Molar Mass | 107.54 |
| Density | 1.168g/mLat 25°C(lit.) |
| Melting Point | −33°C(lit.) |
| Boling Point | 167-168°C775mm Hg(lit.) |
| Flash Point | 155°F |
| Water Solubility | Decomposes |
| Vapor Presure | 1.76mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.172 |
| Color | Colorless to Yellow |
| Exposure Limit | ACGIH: TWA 0.005 ppm (Skin) |
| BRN | 878197 |
| pKa | -1.85±0.70(Predicted) |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.453 |
| Physical and Chemical Properties | Traits colorless or light yellow to light brown irritating oily liquid. melting point -33 ℃ boiling point 167 ℃ |
| Use | Used as pharmaceutical, pesticide intermediates |
Dimethylcarbamoyl chloride - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R45 - May cause cancer R22 - Harmful if swallowed R23 - Toxic by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S99 - |
| UN IDs | UN 2262 8/PG 2 |
| WGK Germany | 3 |
| RTECS | FD4200000 |
| FLUKA BRAND F CODES | 9 |
| TSCA | Yes |
| HS Code | 29241990 |
| Hazard Class | 8 |
| Packing Group | II |
| Toxicity | A designated animal carcinogen (IARC) and hazardous waste (EPA); a suspected carcinogen in humans. It is a liquid boiling at 165_x0003_C that is used primarily in the manufacture of drugs and pesticides. Dimethyl carbamoyl chloride is extremely toxic. |
Dimethylcarbamoyl chloride - Upstream Downstream Industry
| Raw Materials | Dimethylamine Dimethylamine Coke(coal) Chlorine |
Dimethylcarbamoyl chloride - Nature
Open Data Verified Data
colorless or light yellow to light brown irritating oily liquid. Melting Point -33 °c. Boiling point 167 °c. Decomposition in water. Soluble in ether, carbon disulfide, benzene and other organic solvents.
Last Update：2024-01-02 23:10:35
Dimethylcarbamoyl chloride - Preparation Method
Open Data Verified Data
with dimethylamine as raw material, and phosgene for formyl chlorination reaction, dimethyl formyl chloride amine crude product, after deacidification to get the finished product.
Last Update：2022-01-01 10:36:28
Dimethylcarbamoyl chloride - Use
Open Data Verified Data
used in the synthesis of pharmaceuticals, pesticides, dyes, plastics and other fine organic chemicals.
Last Update：2022-01-01 10:36:28
Dimethylcarbamoyl chloride - Safety
Open Data Verified Data
- This product is dangerous to burn when exposed to high heat, fire source or oxidant. Lacrimal agent. Corrosive to skin, eyes and mucous membranes. Contact with water or water vapor can produce toxic and corrosive fumes. The eyes are irritated and washed with water, and the severe cases that splash into the eyes should be treated with medical treatment. The skin contact should be washed with water first, then washed thoroughly with soap; Those who inhale steam should leave the contaminated area, rest and keep warm; the patient was immediately gargled and sent to the hospital for treatment.
- This product is packed with plastic bags and external iron barrels.
Last Update：2022-01-01 10:36:29
Dimethylcarbamoyl chloride - Reference Information
| (IARC) carcinogen classification | 2A (Vol. 12, Sup 7, 71) 1999 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | used as an intermediate in medicine and pesticide dimethyl carbamate chloride is a carbamate insecticide, zoxaparb and other intermediates, also used as pharmaceuticals, dyes, synthetic materials and other fine chemicals intermediates, such as for the production of neostigmine bromide, neostigmine methyl sulfate, pyridostigmine et al. used in the synthesis of pharmaceuticals, pesticides, dyes, plastics, synthetic materials and other fine organic chemical products, such as for the production of new stage of bromide, neostigmine methyl sulfate, pyridostigmine, carbamate insecticides, etc. |
| production method | the crude dimethyl formyl chloride Amine was obtained by formyl chlorination reaction with phosgene, the final product was obtained by deacidification. dimethylcarbamoyl chloride is prepared by the reaction of dimethylamine with phosgene. Reaction equation:(CH3)2NH COCl2 →(CH3)2NCOCl toluene was added to the reaction pot, and phosgene was introduced under cooling to absorb the calculated amount. In the other pot, the gas dimethylamine is generated from the dimethylamine aqueous solution, and the reaction is passed into the phosgene toluene solution after drying. After completion of the reaction, the hydrochloride was removed by filtration and distilled under reduced pressure to obtain dimethyl carbamoyl chloride as a fraction at 75 ° C. (3.33kPa). The yield was 55%. Dimethyl carbamate chloride can also be prepared from N,N-dimethyl formamide and phosphorus trichloride after reaction with thionyl chloride. The reaction equation is as follows: HCON(CH3) 2pcl3 →[(CH3)2N = CHOPCl2]Cl-[SOCl2]→(CH3)2NCOCl in addition, it can also be Pd, pdCl2 or RhCl3 is a catalyst prepared by reacting dimethyl ammonium chloride with carbon monoxide. Reaction equation:(CH3)2NCl CO [catalyst] →(CH3)2NCOCl |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:11
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Raw Materials for Dimethylcarbamoyl chloride