HTL-1071

Name	HTL1071
Synonyms	CPD1545 CS-2744 HTL1071 azd4635 AZD4635 AZD-4635 HTL-1071 HTL1071 HTL 1071 HTL-1071 AZD 4635 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine 1,2,4-Triazin-3-amine, 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-
CAS	1321514-06-0

Molecular Formula	C15H11ClFN5
Molar Mass	315.73
Density	1.387±0.06 g/cm3(Predicted)
Boling Point	491.5±55.0 °C(Predicted)
pKa	1.75±0.63(Predicted)
Storage Condition	-20℃
Use	AZD4635 (HTL1071) is an effective selective, orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 Ki binding to human A2AR is 1.7 nM, and the selectivity for A2AR is more than 30 times that of other adenosine receptors.
In vitro study	In CHO cells stably expressing A2AR of human origin, AZD4625 inhibited the generation of IC50 of 0.79, 10.0 and 142.9 nM with the addition of 0.1, 1 and 10 μm adenosine, respectively.
In vivo study	Inhibition of A2AR by AZD4625 can reduce tumor burden and enhance anti-tumor immunity.

Last Update：2024-01-02 23:10:35

biological activity	Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR, the Ki value is 1.7 nM and the selectivity for A2AR is more than 30 times that for other adenosine receptors.
Target	Value
A2AR (Cell-free)	1.7 nM(Ki)

Last Update：2024-04-09 02:00:14

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CAS: 1321514-06-0
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Mobile: 18021002903
QQ: 3008007409

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HTL-1071

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