MDK19922

Name	NOD-IN-1
Synonyms	NOD-IN-1 MDK19922 MDK19922 MDK 19922 MDK-19922. COMPOUND 4 NOD inhibitor 1 1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester
CAS	132819-92-2

Molecular Formula	C18H17NO4S
Molar Mass	343.4
Density	1.27±0.1 g/cm3(Predicted)
Melting Point	98-99 °C
Boling Point	523.3±52.0 °C(Predicted)
Solubility	10 mM in DMSO
Storage Condition	2-8°C
In vitro study	NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC 50 (NOD1)=5.74 μM; IC 50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.

Last Update：2024-01-02 23:10:35

biological activity	NOD-IN-1 (MDK19922, Compound 4) it is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2, corresponding to IC50 values of 5.74 μm and 6.45 μm, respectively.
Target	IC50: 5.74 μm (NOD1), 6.45 μm (NOD2)

Last Update：2024-04-09 20:49:11

Spot supply

Product Name: NOD-IN-1 Visit Supplier Webpage Request for quotation
CAS: 132819-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Spot supply

Product Name: NOD-IN-1 Visit Supplier Webpage Request for quotation
CAS: 132819-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

MDK19922

MDK19922 Request for Quotation