NVP-HDM201

Name	NVP-HDM201
Synonyms	HDM201 HDM-201 CS-2787 CS-2613 HDM-201 HDM 201 NVP-HDM201 Siremadlin NVP-HDM201 NVP-HDM 201 NVP-HDM-201 (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one (6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one
CAS	1448867-41-1

Molecular Formula	C26H24Cl2N6O4
Molar Mass	555.41
Density	1.47±0.1 g/cm3(Predicted)
Boling Point	736.5±70.0 °C(Predicted)
Solubility	DMSO
pKa	1.33±0.29(Predicted)
Storage Condition	-20℃
MDL	MFCD30502893
In vitro study	HDM201 binds to the p53 binding site of the Mdm2 protein, disrupting the interaction between the two proteins, leading to activation of the p53 pathway. HDM201 is capable of inducing potent, p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. HDM201 is highly selective in a variety of cancer cell lines.
In vivo study	HDM201 has good pharmacokinetic, pharmacodynamic properties and oral bioavailability in animal models. In a variety of human cancer xenograft models carrying wild-type p53, dosing with a variety of dosage schedules can cause rapid, sustained activation of p53-dependent pharmacodynamic biomarkers, resulting in tumor regression.

Last Update：2024-01-02 23:10:35

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Product Name: NVP-HDM201 Visit Supplier Webpage Request for quotation
CAS: 1448867-41-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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NVP-HDM201

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