PF 6700841
PF-06700841 tosylate
CAS: 1883299-62-4
Molecular Formula: C18H21F2N7O
PF 6700841 - Names and Identifiers
PF 6700841 - Physico-chemical Properties
| Molecular Formula | C18H21F2N7O |
| Molar Mass | 389.4 |
| Density | 1.63±0.1 g/cm3(Predicted) |
| Boling Point | 637.1±65.0 °C(Predicted) |
| Appearance | powder |
| Color | white to beige |
| pKa | 7.28±0.10(Predicted) |
| Storage Condition | room temp |
| In vivo study | PF-06700841 pharmacokinetic studies in Sprague − Dawley rats after intravenous injection of 1 mg/kg PF-06700841 tosylate or oral administration of 3 mg/kg PF-06700841 tosylate, the plasma clearance of PF-06700841 in vivo was 31 mL/min/kg, the volume of distribution was 2.0 L/kg, and its oral bioavailability was 83%. After oral administration of 3 mg/kg, its Cmax was 774 ng/mL and auc∞ was 1340 ng · h/mL. The high oral bioavailability of PF-06700841 indicates that it has a high intestinal Absorbability, which is associated with its passive osmotic activity and high solubility in vitro. |
PF 6700841 - References
| biological activity | PF-06700841 (PF-841) is a potent Tyk2 and Jak1 inhibitor, the IC50 for Jak1 and Jak2 are 23 nM, 17 nM and 77 nM, respectively. |
| Target | Value |
| JAK1 (Cell-free assay) | 17 nM |
| Tyk2 (Cell-free assay) | 23 nM |
| JAK2 (Cell-free assay) | 77 nM |
Last Update：2024-04-09 21:04:16
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CAS: 1883299-62-4
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CAS: 1883299-62-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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