(2-Bromoethyl)benzene
(2-Bromoethyl)benzene
CAS: 103-63-9
Molecular Formula: C8H9Br
(2-Bromoethyl)benzene - Names and Identifiers
| Name | (2-Bromoethyl)benzene |
| Synonyms | PHENETHYL BROMIDE Phenethyl bromide 2-phenethylbromide 2-Phenethyl bromide 2-Bromoethyl-benzene β-Bromoethyl benzene PHENYL ETHYL BROMIDE (2-Bromoethyl)benzene 2-Phenylethyl bromide (2-bromoethyl)-benzen 1-BROMO-2-PHENYLETHANE 2-Phenyl-1-bromoethane beta-Bromophenylethane .beta.-Phenylethylbromide |
| CAS | 103-63-9 |
| EINECS | 203-130-8 |
| InChI | InChI=1/C8H9Br/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2 |
| InChIKey | WMPPDTMATNBGJN-UHFFFAOYSA-N |
(2-Bromoethyl)benzene - Physico-chemical Properties
| Molecular Formula | C8H9Br |
| Molar Mass | 185.06 |
| Density | 1.355g/mLat 25°C(lit.) |
| Melting Point | -56 °C |
| Boling Point | 220-221°C(lit.) |
| Flash Point | 193°F |
| Water Solubility | INSOLUBLE |
| Solubility | 0.039g/l |
| Vapor Presure | 0.167mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to pale yellow |
| BRN | 507487 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | n20/D 1.556(lit.) |
| Physical and Chemical Properties | Boiling Point: 217-221 ℃ flash point: 89 ℃ relative density: 1.359-1.370 refractive index (n20D):1.556-1.558 |
| Use | For pharmaceutical and pesticide intermediates |
(2-Bromoethyl)benzene - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S39 - Wear eye / face protection. |
| UN IDs | UN 1993 / PGIII |
| WGK Germany | 3 |
| RTECS | CY9032000 |
| TSCA | Yes |
| HS Code | 29036990 |
(2-Bromoethyl)benzene - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | β-bromostyrene is an important intermediate for the synthesis of high efficient brominated flame retardant polybrominated styrene, it is also commonly used in the preparation of intermediates in organic synthesis. For example, β-bromophenylethane can be used to prepare the intermediate 4-(4-phenylbutoxy) benzoic acid in the preparation of pranlukast. as an anti-asthma drug, pranlukast was first developed by the Japanese Little Wild Company and was marketed in Japan in 1995. In 1999, it was found to treat allergic rhinitis. Pranlukast is a leukotriene C4/D4 receptor antagonist (lTRAs) with extremely low toxicity. It can selectively inhibit the activity of airway smooth muscle leukotriene polypeptides and has little effect on arachidonic acid metabolism enzymes, at the same time, it has no antagonistic effect on acetylcholine and serotonin, and has significant inhibition on lTC4, lTD4, lTE4 and so on. |
| Use | organic synthesis, pesticide intermediates. used as pharmaceutical and pesticide intermediates |
| production method | is derived from the reaction of phenylethyl alcohol with hydrogen bromide. Phenyl ethanol was heated to 110 ° C., hydrogen bromide was slowly introduced, and the reaction was refluxed. After completion of the reaction, the reaction mixture was cooled and washed with water, 10% sodium carbonate solution and water in this order. After drying with anhydrous potassium carbonate and fractional distillation under reduced pressure, the 97-99 ° C. (2.0kPa) fraction was collected, and the yield was more than 90%. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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