(2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester
Z-HYP-OME
CAS: 64187-48-0
Molecular Formula: C14H17NO5
(2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester - Names and Identifiers
(2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester - Physico-chemical Properties
| Molecular Formula | C14H17NO5 |
| Molar Mass | 279.29 |
| Density | 1.313 |
| Boling Point | 422.8±45.0 °C(Predicted) |
| Appearance | Shape viscous liquid color Pale yellow |
| Color | Pale yellow |
| pKa | 14.25±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
(2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester - Risk and Safety
| WGK Germany | 3 |
(2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester - Upstream Downstream Industry
| Downstream Products | 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- N-BOC-cis-4-fluoro-L-proline |
(2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester - Introduction
Z-HYP-OME(Z-HYP-OME) is a compound whose chemical structure contains a N-CBZ group (with a protected amino terminus) and an ester group. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: usually white to light yellow crystalline powder;
-Melting point: about 78-79 ° C;
-Solubility: Soluble in common organic solvents such as methanol, ethanol and dichloromethane.
Use:
- Z-HYP-OME is often used as a reaction substrate, intermediate or catalyst in organic synthesis;
-Mainly used in the synthesis of polypeptide compounds, especially hydroxyproline-related polypeptides and peptide drugs.
Method:
-The preparation of Z-HYP-OME is usually prepared by reacting N-protected trans-L-hydroxyproline (Z-HYP) with a methyl esterification reagent in methanol;
-Optional methyl esterification reagents include methanol and methyl formate, and the reaction is usually carried out at room temperature.
Safety Information:
- Z-HYP-OME there is no specifically reported toxicity or risk information;
-It is still necessary to pay attention to safe operation measures during use, such as wearing appropriate personal protective equipment and operating in a well-ventilated environment.
It is important to note that for any chemical substance, please follow the appropriate laboratory safety procedures. When using and handling chemicals, ensure adequate safety knowledge and laboratory skills, and follow correct operating techniques and laboratory regulations.
Nature:
-Appearance: usually white to light yellow crystalline powder;
-Melting point: about 78-79 ° C;
-Solubility: Soluble in common organic solvents such as methanol, ethanol and dichloromethane.
Use:
- Z-HYP-OME is often used as a reaction substrate, intermediate or catalyst in organic synthesis;
-Mainly used in the synthesis of polypeptide compounds, especially hydroxyproline-related polypeptides and peptide drugs.
Method:
-The preparation of Z-HYP-OME is usually prepared by reacting N-protected trans-L-hydroxyproline (Z-HYP) with a methyl esterification reagent in methanol;
-Optional methyl esterification reagents include methanol and methyl formate, and the reaction is usually carried out at room temperature.
Safety Information:
- Z-HYP-OME there is no specifically reported toxicity or risk information;
-It is still necessary to pay attention to safe operation measures during use, such as wearing appropriate personal protective equipment and operating in a well-ventilated environment.
It is important to note that for any chemical substance, please follow the appropriate laboratory safety procedures. When using and handling chemicals, ensure adequate safety knowledge and laboratory skills, and follow correct operating techniques and laboratory regulations.
Last Update：2024-04-09 19:05:55
Supplier List
View History
Downstream Products for (2S,4R)-1-Benzyloxycarbonyl-4-hydroxypyrrolidin-2-carboxylic acid methyl ester