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(Diacetoxyiodo)benzene

Iodobenzene diacetate

CAS: 3240-34-4

Molecular Formula: C10H11IO4

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(Diacetoxyiodo)benzene - Names and Identifiers

Name Iodobenzene diacetate
Synonyms PIA
DAIB
AURORA KA-6690
diacetoxyiodo-benzen
Iodobenzene diacetate
PHENYLIODINE DIACETATE
(Diacetoxyiodo)benzene
DIACETOXYIODOSOBENZENE
(DIACETOXYIODO)BENZENE
LABOTEST-BB LT00847235
Iodosobenzene diacetate
IODOBENZENE I,I-DIACETATE
iodosylbenzene di(acetate)
Phenyliodine(III) diacetate
bis(acetyloxy)(phenyl)-lambda~3~-iodane
CAS 3240-34-4
EINECS 221-808-1
InChI InChI=1/C6H5I.2C2H4O2/c7-6-4-2-1-3-5-6;2*1-2(3)4/h1-5H;2*1H3,(H,3,4)
InChIKey ZBIKORITPGTTGI-UHFFFAOYSA-N

(Diacetoxyiodo)benzene - Physico-chemical Properties

Molecular FormulaC10H11IO4
Molar Mass322.1
Density1.6865 (estimate)
Melting Point161-163 °C (lit.)
Boling Point456.8°C at 760 mmHg
Flash Point230.1°C
Water SolubilityINSOLUBLE
Solubility INSOLUBLE
Vapor Presure3.87E-09mmHg at 25°C
AppearanceWhite crystal
ColorClear to cloudy colorless to yellow
BRN1879369
Storage ConditionKeep in dark place,Sealed in dry,Room Temperature
StabilityLight and Moisture sensitive
SensitiveLight Sensitive
Refractive Indexn/D 1.444
MDLMFCD00008692
Physical and Chemical PropertiesMP 161-165°C
UseUsed as an intermediate of topotecan

(Diacetoxyiodo)benzene - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S37/39 - Wear suitable gloves and eye/face protection
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S27 - Take off immediately all contaminated clothing.
UN IDs1479
WGK Germany3
RTECSDA3525000
FLUKA BRAND F CODES4.10-8
TSCAYes
HS Code29310095
Hazard NoteIrritant
Hazard Class6.1(b)
Packing GroupIII

(Diacetoxyiodo)benzene - Introduction

Insoluble in water.
Last Update：2022-10-16 17:24:35

(Diacetoxyiodo)benzene - Reference Information

NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
traits white to off-white crystalline powder.
application iodophenyl diacetic acid is used in pharmaceutical and other industries. it has good selective oxidation characteristics and has been more and more widely used in recent years. For example, the latest oral lung cancer treatment drug topotecan, the anti-inflammatory analgesic naproxen, the antidepressant fluoxetine, and the influenza drug oseltamivir (Tamiflu) to deal with avian influenza, and the synthesis of anti-tumor drug Aranorosin. It is also used for Hoffman degradation, such as unnatural amino acids L-2, 3-diaminopropionic acid, L-2, the synthesis of 4-diaminobutyric acid, the catalytic halogenation, the ring formation of heterocyclic compounds such as benzimidazole, the oxidation of phenol, the oxidation reaction of porphyrin, etc., the product has a wide range of uses, stable properties, easy to store, and the reaction The by-product is usually the more expensive organic raw material iodobenzene, which can be recycled and recycled, and can also be used to synthesize other compounds without polluting the environment. It is a very ideal oxidation reagent.
Preparation method Method 1: A preparation method of iodophenyl diacetic acid, this method uses sodium perborate tetrahydrate as raw material, in the presence of glacial acetic acid/acetic anhydride mixture Acylation reaction with iodobenzene, in which the molar ratio of sodium perborate tetrahydrate to iodobenzene is 3-10: 1, and the reaction temperature is 30 ℃ -45 ℃, the reaction time is 4-24 hours. After the reaction is over, ice water is added to obtain crude iodiphenyl diacetic acid, and then recrystallized to obtain iodiphenyl diacetic acid. Method 2: Efficient and environmentally friendly preparation method of iodophenyl diacetic acid: using iodobenzene as the starting material, acetic acid as the solvent, reacting with peracetic acid, adding water to precipitate iodophenyl diacetic acid. Specifically, it includes: adding iodobenzene and acetic acid to the reaction bottle, controlling the temperature to 30-40 ℃, adding peracetic acid dropwise, stirring for 5 hours after dropping, cooling to 5-10 ℃, centrifuging, washing the filter cake with water and n-heptane in turn, and drying to obtain iodophenyl diacetic acid.
Use Used as topotecan intermediate
Mild oxidant
Biochemical research
Multifunctional oxidation and acetic acid reagent; In the reaction of TEMPO oxidizing nerol to neraldehyde, the oxidizing agent is stoichiometric; the oxidizing agent in the azirylation reaction of alkene and sulfamate catalyzed by rhodium; used for palladium-catalyzed 2-arylation of indole at room temperature; used for the synthesis of a wide variety of heterocyclic compound reagents; vic-ethylene glycol lysating agent, hydroxylation and many oxidation reactions; used for the preparation of thermally unstable substances Iodine benzene
Rhodium-catalyzed olefin azacyclic propane sulfonate oxidant. A useful reagent for the synthesis of various heterocyclic compounds using palladium-catalyzed 2-arylation of indole at room temperature.
Last Update：2024-04-10 22:41:30
(Diacetoxyiodo)benzene
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Tel: +86-17551318830
Email: r@reformchem.com
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Tel: +86-17551318830
Email: r@reformchem.com­
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Email: 2470479589@qq.com
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Jiangsu Pules Biotechnology Co.,Ltd.
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CAS: 3240-34-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hubei Longxin Chemical Industry Co., Ltd
Spot supply
Product Name: (Diacetoxyiodo)benzene Request for quotation
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Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276 Click to send a QQ message
Wechat: A2020071098
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Iodobenzene diacetate Request for quotation
CAS: 3240-34-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: (Diacetoxyiodo)benzene Visit Supplier Webpage Request for quotation
CAS: 3240-34-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: (Diacetoxyiodo)benzene Request for quotation
CAS: 3240-34-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Iodobenzene diacetate Request for quotation
CAS: 3240-34-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
Shanghai Yuli Biotechnology Co.,Ltd.
Product Name: Iodobenzene  diacetate Request for quotation
CAS: 3240-34-4
Tel: 13501999454
Email: yuki@yulibiotech.com
Mobile: 13501999454
QQ: 544600049 Click to send a QQ messageSend QQ message
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(Diacetoxyiodo)benzene
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