(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde
2,3-O-isopropylidene-D-glyceraldehyde
CAS: 15186-48-8
Molecular Formula: C6H10O3
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde - Names and Identifiers
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C6H10O3 |
| Molar Mass | 130.14 |
| Density | 1.045 g/mL at 25 °C (lit.) |
| Boling Point | 139 °C (lit.) |
| Specific Rotation(α) | 53.8 º (c=2, CHCl3) |
| Flash Point | 143°F |
| Solubility | Difficult to mix. |
| Appearance | Liquid |
| Color | Colorless to Pale Yellow |
| Storage Condition | -20°C |
| Refractive Index | n20/D 1.454(lit.) |
| Physical and Chemical Properties | Boiling point 139°C specific rotation 53.8 ° (c = 2, CHCl3) |
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29329990 |
| Hazard Class | 6.1 |
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | (R)-( )-2, 2-dimethyl-1, 3-dioxole-4-formaldehyde, also known as R-glyceraldehyde acetone, is an intermediate in the synthesis of gemcitabine. Gemcitabine hydrochloride is a new synthetic difluoronucleoside anti-metabolic anti-tumor drugs, the product was first developed by the United States elilly company, trade name "Gemzar". Gemcitabine hydrochloride can inhibit DNA synthesis. |
| preparation | 220g of dichloromethane and 23g of diacetone-D-mannitol were sequentially added to the clean reactor, 18-crown -6-ether 0.23g,TEMPO 0.4g, after mixing evenly, slowly cool to 10 ℃, and then add 72g of sodium hypochlorite aqueous solution with mass percentage of 10wt% dropwise, during the dropwise addition, the temperature of the reaction system is controlled to be below 15 ° C. After the dropwise addition is completed, the reaction is continued so that the temperature is maintained at 30 ° C. To 32 ° C. For the oxidation reaction for 1H, after the reaction is finished, stand, layer, remove the water layer, collect the organic layer with 50g water once, layer to remove the water layer, the collected organic layer is added 20g anhydrous sodium sulfate and stirred for drying treatment for 30min, Suction filtration, the filtrate was collected, and the filtrate was concentrated under reduced pressure to remove the solvent, and the obtained wet product was baked to obtain dry product (R)-( )-2, 2-dimethyl-1, 3-dioxolane -4-formaldehyde 22.1g, yield 97%, gas phase content 99.2%. |
Last Update：2024-04-10 22:41:03
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View History
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde
AMPS2405钠盐溶液
1, 2-环已烷二羧酸二异壬基酯
2-碘-5-苯基恶唑
ASCORBYL GLUCOSIDE
1-(2-氨乙基)哌啶
SOLID ACRYLATE EPOXY
C.I.PigmentRed32
4-氨基苯甲酸叔-丁基酯
吡啶-3-羧酸钠
AMPS2405钠盐溶液
1, 2-环已烷二羧酸二异壬基酯
2-碘-5-苯基恶唑
ASCORBYL GLUCOSIDE
1-(2-氨乙基)哌啶
SOLID ACRYLATE EPOXY
C.I.PigmentRed32
4-氨基苯甲酸叔-丁基酯
吡啶-3-羧酸钠