α-Chaconine from potato sprouts
alpha-chaconine from potato sprouts
CAS: 20562-03-2
Molecular Formula: C45H73NO14
α-Chaconine from potato sprouts - Names and Identifiers
| Name | alpha-chaconine from potato sprouts |
| Synonyms | CHACONINE CHACONINE, A- ALPHA-CHACONIN ALPHA-CHACONINE ALPHA-CHACOCINE A-CHACONINE WITH TLC A-CHACONINE FROM POTATO SPROUTS α-Chaconine from potato sprouts alpha-chaconine from potato sprouts |
| CAS | 20562-03-2 |
| InChI | InChI=1/C45H73NO14/c1-19-7-10-28-20(2)31-29(46(28)17-19)16-27-25-9-8-23-15-24(11-13-44(23,5)26(25)12-14-45(27,31)6)57-43-40(60-42-37(53)35(51)33(49)22(4)56-42)38(54)39(30(18-47)58-43)59-41-36(52)34(50)32(48)21(3)55-41/h8,19-22,24-43,47-54H,7,9-18H2,1-6H3/t19-,20+,21-,22-,24?,25+,26-,27?,28+,29-,30+,31-,32-,33-,34+,35+,36+,37+,38-,39?,40+,41-,42-,43+,44-,45-/m0/s1 |
α-Chaconine from potato sprouts - Physico-chemical Properties
| Molecular Formula | C45H73NO14 |
| Molar Mass | 852.06 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Melting Point | 228-236°C |
| Solubility | pyridine: 10 mg/mL, clear, very faintly yellow |
| Appearance | Powder |
| Color | White to Off-White |
| pKa | 12?+-.0.70(Predicted) |
| Storage Condition | −20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.621 |
| In vitro study | α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling. |
α-Chaconine from potato sprouts - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 63 - Possible risk of harm to the unborn child |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | FL6700000 |
| FLUKA BRAND F CODES | 10 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
α-Chaconine from potato sprouts - Reference
| Reference Show more | 1. Zhong Shihao, Ren Xinxin, Huang Jian, Luan Yujing, Yu Zhongshan. Detection of Four Food-borne Toxic Alkaloids in Corrupt Blood and Liver by QuEChERS/Ultra High Liquid Chromatography-Tandem Mass Spectrometry [J]. Chemical Research and Application 2020 v.32(07):24-31. 2. He Yuhua, Jia Xiaoman, Xu Xuexue, Wen Ya. Effects of different concentrations of α-carcinine on the proliferation rate of small intestinal mucosal epithelial cells in piglets [J]. Livestock and Feed Science 2019 40(04):15-17. 3. [IF = 4.402] He Yuhua et al."α-Chaconine Affects the Apoptosis, Mechanical Barrier Function, and Antioxidant Ability of Mouse Small Intestinal Epithelial Cells." Front Plant Sci. 2021 Jun;12:1122 |
α-Chaconine from potato sprouts - Reference Information
| biological activity | α-Chaconine, isolated from Solanum tuberosum L. cv Jayoung, can inhibit COX-2,IL-1β,IL-6 and TNF-α expression at the transcriptional level. α-Chaconine acts on RAW 264.7 macrophages to inhibit LPS-induced iNOS and COX-2 expression and its promoter activity at protein and mRNA levels. Alpha-Chaconine has anti-inflammatory effects. |
| target | COX-2 |
| in vitro study | α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects ice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-rat LD50: 84 mg/kg; Abdominal cavity-mouse LD50: 19 mg/ |
| flammability hazard characteristics | thermal decomposition spicy stimulation smoke |
| storage and transportation characteristics | warehouse low temperature ventilation and drying; separate from food raw materials |
| fire extinguishing agent | water, carbon dioxide, foam, dry powder |
Last Update：2024-04-09 15:16:38
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