α-amino-3-hydroxy-5-isoxazoleaceticacid
IBOTENIC ACID
CAS: 2552-55-8
Molecular Formula: C5H6N2O4
α-amino-3-hydroxy-5-isoxazoleaceticacid - Names and Identifiers
α-amino-3-hydroxy-5-isoxazoleaceticacid - Physico-chemical Properties
| Molecular Formula | C5H6N2O4 |
| Molar Mass | 158.11 |
| Density | 1.621±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 141-147 °C |
| Boling Point | 458.8±45.0 °C at 760 mmHg |
| Solubility | Dissolvable 20mg in 1ml of 1mol/L NH4OH |
| Appearance | White solid |
| Storage Condition | -20℃ |
| Sensitive | Sensitive to water |
| MDL | MFCD00069294 |
| Physical and Chemical Properties | The bioactive Ibotenic acid has agonist activity on both N-methyl-D-aspartate (NMDA) and trans-ACPD or metabotropic aspartate (Qm) receptor sites. |
α-amino-3-hydroxy-5-isoxazoleaceticacid - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R25 - Toxic if swallowed R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
| UN IDs | 1544 |
α-amino-3-hydroxy-5-isoxazoleaceticacid - Reference
| Reference Show more | 1. [IF=3.386] Mouxiao Su et al.Effects of fastigial nucleus electrostimulation on cardiac nerve regeneration, neurotransmitter release, and malignant arrhythmia inducibility in a post-infarction rat model.European Journal Of Neuroscience.2021 Nov 18 |
α-amino-3-hydroxy-5-isoxazoleaceticacid - Introduction
botenic acid has agonist activity on both N-methyl-D-aspartate (NMDA) and trans-ACPD or metabotropic aspartate (Qm) receptor sites.
Last Update：2022-10-16 17:30:46
α-amino-3-hydroxy-5-isoxazoleaceticacid - Nature
| melting point | 141-147 °C |
| density | 1.621±0.06 g/cm3 (20°C 760 Torr) |
| storage conditions | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: soluble1mg/mL, clear, colorless (with sonication) |
| acidity coefficient (pKa) | 2.16±0.10(Predicted) |
| morphology | White solid |
| color | white |
| InChIKey | IRJCBFDCFXCWGO-UHFFFAOYSA-N |
Last Update：2024-04-10 22:29:15
α-amino-3-hydroxy-5-isoxazoleaceticacid - Uses and synthesis methods
target
NMDA receptor
in vitro study
Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC 50 =77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media.
Last Update：2024-04-09 20:48:19
α-amino-3-hydroxy-5-isoxazoleaceticacid - Security information
| dangerous goods mark | T,Xn |
| hazard category code | 23/24/25-25-40 |
| safety instructions | 45-38-36/37/39-28A-22-36 |
| dangerous goods transport number | 1544 |
| WGK Germany | 3 |
| RTECS number | NY2100000 |
| HazardClass | 6.1( B ) |
| PackingGroup | III |
| Toxicity | LD50 in mice, rats (mg/kg): 15, 42 I .v.; 38, 129 orally (Theobald) |
Last Update：2024-04-09 20:49:11
Supplier List
Multiple SpecificationsSpot supply
Product Name: (RS)-Ibotenic acid Visit Supplier Webpage Request for quotationCAS: 2552-55-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: (RS)-Ibotenic acid Visit Supplier Webpage Request for quotationCAS: 2552-55-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History