α-hederin 27013-91-8
α-hederin
CAS: 27013-91-8
Molecular Formula: C41H66O12
α-hederin 27013-91-8 - Names and Identifiers
| Name | α-hederin |
| Synonyms | HELIXIN nepalin2 α-hederin koronarosidea ALPHA-HEDERIN kizutasaponink6 α-hederin 27013-91-8 alpha-Hederin (α-Hederin) olean-12-en-28-oicacid,3-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabi |
| CAS | 27013-91-8 |
| EINECS | 248-166-5 |
| InChIKey | KBKXVOJBOOKRQW-OGHMGUQHSA-N |
α-hederin 27013-91-8 - Physico-chemical Properties
| Molecular Formula | C41H66O12 |
| Molar Mass | 750.96 |
| Density | 1.32 |
| Melting Point | 215°C (dec.) |
| Boling Point | 849.6±65.0 °C(Predicted) |
| Specific Rotation(α) | D20 +14.5° (c = 0.92 in methanol) |
| Solubility | Soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. |
| Appearance | White powder |
| pKa | 4.63±0.70(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00010665 |
| Physical and Chemical Properties | White crystalline powder, soluble in water, methanol, ethanol, derived from foreseen. |
| In vitro study | alpha-Hederin (α-Hederin) is cytotoxic and inhibits proliferation in both cel lines at rather low concentrations. alpha-Hederin (α-Hederin)reduces the mitotic activity in treated cells. |
| In vivo study | alpha-Hederin (α-Hederin) has preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses. |
α-hederin 27013-91-8 - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | RK0177800 |
| HS Code | 29389090 |
α-hederin 27013-91-8 - Reference
| Reference Show more | 1. [IF=6.529] Dongdong Sun et al."α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells."Biomed Pharmacother. 2018 May;101:107 2. [IF=2.197] Dongdong Sun et al."-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-B Signaling in Colon Cancer Cells."Biomed Res Int. 2018; 2018: 2548378 3. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 |
α-hederin 27013-91-8 - Reference Information
| biological activity | alpha-Hederin (α-Hederin) is a single-bridged sugar triterpene saponin, which has a good anti-tumor effect on a variety of tumor cells. alpha-Hederin can inhibit gastric cancer cell proliferation and induce apoptosis (apoptosis) by activating mitochondrial-dependent pathway, accompanied by glutathione reduction and reactive oxygen generation. |
| in vitro study | alpha-Hederin is cytotoxic and inhibits proliferation in both cel lines at rather low concentrations. alpha-Hederin reduces the mitotic activity in treated cells. |
| in vivo study | alpha-Hederin (α-Hederin) has preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses. |
| chemical properties | white crystalline powder, soluble in water, methanol, ethanol, derived from the prophecy. |
| use | α-ivy saponin has an antidepressant effect. used for content determination/identification/pharmacological experiment, etc. Pharmacological effect: has certain cytotoxic activity. |
Last Update：2024-04-09 20:45:29
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Mobile: 18021002903
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