β-Carboline-3-carboxylic acid N-methylamide
N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE
CAS: 78538-74-6
Molecular Formula: C13H11N3O
β-Carboline-3-carboxylic acid N-methylamide - Names and Identifiers
β-Carboline-3-carboxylic acid N-methylamide - Physico-chemical Properties
| Molecular Formula | C13H11N3O |
| Molar Mass | 225.25 |
| Density | 1.328±0.06 g/cm3(Predicted) |
| Boling Point | 576.3±30.0 °C(Predicted) |
| Solubility | ethanol: 1mg/mL |
| Color | light tan |
| pKa | 13.44±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Use | FG 7142 (ZK 39106; LSU-65) is a non-selective benzodiazepine inverse agonist with high affinity (Ki = 91 nM) for GABAA receptor containing α1 subunit. FG 7142 (ZK 39106; LSU-65) also regulates GABA-induced chlorine flux (EC50=137 nM) on GABAA receptors expressing the α1 subunit. FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and lead to upregulation of β-adrenoceptors in mouse cerebral cortex. |
| In vitro study | FG-7142 has affinity for those expressing the α subunit, the K i values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively. FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC 50 = 137 nM) as compared to the other α subunits (EC 50 : α2= 507 nM,α3=1.021μM , α5=1.439 μM). |
| In vivo study | FG-7142 (intraperitonealinjection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats. FG-7142 (intraperitonealinjection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas. |
β-Carboline-3-carboxylic acid N-methylamide - Risk and Safety
| WGK Germany | 3 |
| RTECS | UU9780100 |
β-Carboline-3-carboxylic acid N-methylamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.44 ml | 22.198 ml | 44.395 ml |
| 5 mM | 0.888 ml | 4.44 ml | 8.879 ml |
| 10 mM | 0.444 ml | 2.22 ml | 4.44 ml |
| 5 mM | 0.089 ml | 0.444 ml | 0.888 ml |
Last Update：2024-01-02 23:10:35
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Product Name: N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE Visit Supplier Webpage Request for quotationCAS: 78538-74-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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