β-N-dimethylaminopropionitrile
3-(Dimethylamino)propionitrile
CAS: 1738-25-6
Molecular Formula: C5H10N2
β-N-dimethylaminopropionitrile - Names and Identifiers
β-N-dimethylaminopropionitrile - Physico-chemical Properties
| Molecular Formula | C5H10N2 |
| Molar Mass | 98.15 |
| Density | 0.87g/mLat 25°C(lit.) |
| Melting Point | −43°C(lit.) |
| Boling Point | 171°C750mm Hg(lit.) |
| Flash Point | 145°F |
| Water Solubility | 0.5 g/L (20 ºC) |
| Vapor Presure | 1.24mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to yellow |
| BRN | 773779 |
| pKa | 8.17±0.28(Predicted) |
| PH | 10.8 (100g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Explosive Limit | 1.6-11.4%(V) |
| Refractive Index | n20/D 1.426(lit.) |
| Physical and Chemical Properties | Β-dimethylaminopropionitrile is a colorless liquid, B. p.172 ~ 174 ℃,n20D 1.4255, relative density of 0.870, can be miscible with most organic solvents. |
| Use | Determination of molecular weight of protein, enzyme and nucleic acid by disc electrophoresis in nitrogenase cell analysis |
β-N-dimethylaminopropionitrile - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R36/38 - Irritating to eyes and skin. R21 - Harmful in contact with skin |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2927 |
| WGK Germany | 1 |
| RTECS | UG1575000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29269095 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
β-N-dimethylaminopropionitrile - Nature
Open Data Verified Data
colorless transparent liquid. Melting Point -44.3 °c. Boiling point 171~173 deg C. Relative density 0.8705. Refractive index 4258. Flash point 62 °c. Flammable. This product tends to turn yellow when exposed to air. Difficult to dissolve in water, can be miscible with alcohol, ether, benzene.
Last Update：2024-01-02 23:10:35
β-N-dimethylaminopropionitrile - Preparation Method
Open Data Verified Data
is derived from the interaction of dimethylamine with acrylonitrile. Acrylonitrile is first added to dimethylamine solution under ice-cooling, then heated, and the fraction at 171-173 ℃ is collected through absorption and fractional distillation to obtain this product.
Last Update：2022-01-01 10:36:58
β-N-dimethylaminopropionitrile - Use
Open Data Verified Data
organic synthesis intermediates for the synthesis of a variety of vitamin B, can also be used as organic solvents, polymer synthesis initiator and Analytical reagents.
Last Update：2022-01-01 10:36:57
β-N-dimethylaminopropionitrile - Safety
Open Data Verified Data
It is reported that the toxicity of this product is not too large, but the effect of the vapor is more dangerous than the oral input of this product. Oral LD50 for mice was 1500g/kg. The equipment should be sealed, and the operator should wear protective equipment. This product is stored and transported according to the provisions of toxic chemicals.
Last Update：2022-01-01 10:36:58
β-N-dimethylaminopropionitrile - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | β-dimethylaminopropionitrile is an intermediate of the fungicide, downy. organic synthesis intermediates, used in the synthesis of a variety of vitamin B, can also be used as organic solvents, polymer synthesis initiator (polymerization promoter) and electroplating additives intermediates. The analysis reagent is used for the measurement of protein, enzyme, and plum molecular weight by disc electrophoresis in the analysis of nitrogenase cells. determination of molecular weight of protein, enzyme and nucleic acid by disc electrophoresis in nitrogenase cell analysis |
| production method | is derived from the reaction of acrylonitrile with dimethylamine. Acrylonitrile is first added to the dimethylamine solution under ice-cooling, then heated, and the fraction at 171-173 ° C. Is collected by absorption and fractional distillation to obtain the product. Raw material consumption quota: acrylonitrile 670kg/t, dimethylamine (40%)1500kg/t. The preparation method is to put acrylonitrile into the reaction kettle, start stirring and jacket water, inject dimethylamine gas to a specified amount at an appropriate temperature, and sample and analyze the product after 1H of reaction. Reaction equation: CH2 = CHCN +(CH3)2NH →(CH3)2NCH2CH2CN |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2600 mg/kg; Oral-mouse LD50: 1500 mg/kg |
| stimulation data | Skin-rabbits 500 mg/24 h mild; eye-rabbit 20 mg/24 h moderate |
| flammability hazard characteristics | open flame flammable; Highly toxic nitrile-containing gas emitted by heat |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Separate from food, oxidant and acid |
| fire extinguishing agent | water, foam, dry powder, carbon dioxide, sand |
| Occupational Standard | SEL 10 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:45:29
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