γ-Glu-Cys
γ-Glu-Cys
CAS: 636-58-8
Molecular Formula: C8H14N2O5S
γ-Glu-Cys - Names and Identifiers
| Name | γ-Glu-Cys |
| Synonyms | γ-Glu-Cys γ-glu-cys H-GLU(CYS-OH)-OH TFA gamma-glutamylcysteine G-glu-cys trifluoroacetate des-gly-glutathione reduced form GAMMA-GLU-CYS TRIFLUOROACETATE SALT (DES-GLY)-GLUTATHIONE TFA (REDUCED) |
| CAS | 636-58-8 |
| InChIKey | RITKHVBHSGLULN-WHFBIAKZSA-N |
γ-Glu-Cys - Physico-chemical Properties
| Molecular Formula | C8H14N2O5S |
| Molar Mass | 250.27 |
| Density | 1.436±0.06 g/cm3(Predicted) |
| Melting Point | 167℃ |
| Boling Point | 592.4±50.0 °C(Predicted) |
| pKa | 2.21±0.10(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00237863 |
| In vitro study | Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes. |
γ-Glu-Cys - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
γ-Glu-Cys - Introduction
Amino acid sequence: Glu-Cys physical state: Lyophilized from 0.1% TFA.
Last Update：2022-10-16 17:41:44
γ-Glu-Cys - Reference Information
| Biological activity | Gamma-glutamylcysteine (γ-Glutamylcysteine) is a dipeptide containing cysteine and glutamic acid, which is the precursor of glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels. |
Last Update：2024-04-10 22:29:15
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