乙基水杨胺
2-Ethoxybenzamide
CAS: 938-73-8;27043-22-7
Molecular Formula: C9H11NO2
乙基水杨胺 - Names and Identifiers
| Name | 2-Ethoxybenzamide |
| Synonyms | Trancalgyl Etenzamida ETHENZAMIDE Ethenzamide Ethoxybenzamide Ethoxybenzamine 2-ethoxy-benzamid o-Ethoxybenzamide 2-Ethoxybenzamide Etenzamide [DCIT] 2-ETHOXYBENZAMIDE ar-ethoxybenzamide Ethenzamide (JP15) benzamide, 2-ethoxy- 2-ETHOXYBENZOYLAMIDE 2-Ethoxyphenylformamide Salicylamideo-ethylether 2-Ethoxybenzolcarboxamid 2-Ethoxybenzenecarbonamide 2-ETHOXYBENZAMIDE(ETHENZAMIDE) 4-10-00-00175 (Beilstein Handbook Reference) |
| CAS | 938-73-8 27043-22-7 |
| EINECS | 213-346-4 |
| InChI | InChI=1/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11) |
乙基水杨胺 - Physico-chemical Properties
| Molecular Formula | C9H11NO2 |
| Molar Mass | 165.19 |
| Density | 1.1603 (rough estimate) |
| Melting Point | 132-134 °C (lit.) |
| Boling Point | 293.03°C (rough estimate) |
| Flash Point | 153.7°C |
| Water Solubility | <0.1 g/100 mL at 16 ºC |
| Solubility | Chloroform (Slightly), Dichloromethane (Slightly) |
| Vapor Presure | 0.00102mmHg at 25°C |
| Appearance | Granular Crystalline Powder |
| Color | White to almost white |
| Merck | 14,3731 |
| pKa | 15.62±0.50(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5620 (estimate) |
| MDL | MFCD00007977 |
| Physical and Chemical Properties | Melting point 129-134°C water-soluble <0.1g/100 mL at 16°C |
| Use | Used as antipyretic analgesic, for the treatment of Fever, Head Pain, neuralgia, Arthralgia, rheumatoid arthritis, toothache, dysmenorrhea and other diseases |
乙基水杨胺 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | CU4381000 |
| TSCA | Yes |
| HS Code | 29242995 |
| Toxicity | LD50 orally in mice: 1160 mg/kg (Starmer) |
乙基水杨胺 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | 2-ethoxybenzamide is an alkoxybenzamide, which is a new type of pigment image stabilizer in photosensitive materials, this kind of alkoxybenzamide compound is uniformly distributed in the gelatin of the photosensitive dye coupler with fine particles, and can be well mixed with the photosensitive dye coupler, with small turbidity and high transparency, it is an excellent new type of light-sensitive material pigment image stabilizer. |
| Application | 2-ethoxybenzamide has antipyretic and analgesic effects, which is equivalent to aspirin, and no significant gastrointestinal irritation, so not suitable for the use of aspirin headache Fever patients, also apply this drug. |
| Use | This product is an antipyretic analgesic, and its analgesic efficacy is 2.3 times that of salicylic acid amine and 7.5 times that of aspirin. For the treatment of Head Pain, neuralgia, low back pain, rheumatic Arthralgia and colds and so on. The oral LD50 of mice was 1160mg/kg. This product is an antipyretic analgesic, and its analgesic efficacy is 2.3 times that of salicylic acid amine and 7.5 times that of aspirin. For the treatment of Head Pain, neuralgia, low back pain, rheumatic Arthralgia and colds and so on. The oral LD50 of mice was 1160mg/kg. Used as antipyretic analgesic, for the treatment of Fever, Head Pain, neuralgia, Arthralgia, rheumatoid arthritis, toothache, dysmenorrhea and other diseases |
| production method | is derived from the ethylation of Salicylamide (C7H7NO2,[65-45-2]). The Salicylamide, solid sodium hydroxide and ethanol were placed in the reaction Pan, sealed and heated to 60-70 ℃, stirred for 30min, cooled to 30 ℃, bromoethane was added, and then sealed and heated to 80-100 ℃, the pressure is not more than 0.2MPa, and the reaction time is 3H. To atmospheric pressure, pH should be above 8.5. While hot filtration, sodium bromide filter residue recovery. Most of the ethanol was distilled off from the filtrate, and white crystals were precipitated by adding distilled water. Filtration, washing with water until neutral, and drying gave o-ethoxybenzamide. The yield was about 75%. It is also possible to use ethyl chloride instead of ethyl bromide for the ethylation reaction, but higher pressures are required. |
Last Update：2024-04-09 15:16:53
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View History
乙基水杨胺
SODIUM DISULFITE
4-(4,4.5.5-Tetramethyl-1.3.2-dioxaborolan-2-yl)phenethyl Acetate
(2R,3R,4S,5R,6R)-2-溴-6-(((新戊酰氧基)甲基)四氢-2H-吡喃-3,4,5-三基三(2,2-二甲基丙酸酯)(恩格列净杂质)
4-(苯硫基)苯基二苯基硫鎓六氟磷酸盐
异甘草甙
Reactive Black KN-B
N-(2,2-二甲氧基乙基)氨基甲酸叔丁酯
7-isopropyl-5-methylbicyclo[2.2.2]oct-5-ene-2-carbonitrile
2-乙酰氨基-2-脱氧-3-O-(2-乙酰氨基-2-脱氧-ALPAH-D-吡喃半乳糖)-D-吡喃半乳糖
SODIUM DISULFITE
4-(4,4.5.5-Tetramethyl-1.3.2-dioxaborolan-2-yl)phenethyl Acetate
(2R,3R,4S,5R,6R)-2-溴-6-(((新戊酰氧基)甲基)四氢-2H-吡喃-3,4,5-三基三(2,2-二甲基丙酸酯)(恩格列净杂质)
4-(苯硫基)苯基二苯基硫鎓六氟磷酸盐
异甘草甙
Reactive Black KN-B
N-(2,2-二甲氧基乙基)氨基甲酸叔丁酯
7-isopropyl-5-methylbicyclo[2.2.2]oct-5-ene-2-carbonitrile
2-乙酰氨基-2-脱氧-3-O-(2-乙酰氨基-2-脱氧-ALPAH-D-吡喃半乳糖)-D-吡喃半乳糖