伽玛倒捻子素

Name	γ- Mangostin
Synonyms	Nomangostin r-Mangostin Normangostin γ- Mangostin Gamma-mangostin gamma-Mangostin (r-Mangostin) 1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone 1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one 1,3,6,7-Tetrahydroxy-2,8-bis(3-Methylbut-2-en-1-yl)-9H-xanthen-9-one
CAS	31271-07-5

Molecular Formula	C23H24O6
Molar Mass	396.43
Density	1.326±0.06 g/cm3(Predicted)
Melting Point	206-208 °C
Boling Point	648.4±55.0 °C(Predicted)
Solubility	DMSO : 250 mg/mL (630.63 mM; Need ultrasonic)
Appearance	Pale yellow crystalline powder
Color	off-white to yellow
pKa	7.05±0.20(Predicted)
Storage Condition	2-8°C
MDL	MFCD00951752
Physical and Chemical Properties	Soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from mangosteen shells.

biological activity	Gamma-Mangostin is a novel competitive 5-HT2A receptors antagonist purified from the husk of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a transthyretin (TTR) profibrotic inhibitor that binds to the thyroxine (T4) binding site and stabilizes the TTR tetramer. Gamma-Mangostin inhibits the binding of [3H]-spiperone to cultured rat aortic cardiomyocytes (IC50=3.5 nM) and reduces the perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µm).
Target	5-hydroxytryptamine 2A (5-HT2A) receptors
Use	γ-inverted twig has anti-inflammatory, antioxidant, anti-allergic, bactericidal effects. for content determination/identification/pharmacological experiments, etc

Last Update：2024-04-09 20:52:54

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