内-六氢-8-羟基-2,6-亚甲基-2H-喹嗪-3(4H)-酮

内-六氢-8-羟基-2,6-亚甲基-2H-喹嗪-3(4H)-酮 - Names and Identifiers

Name	(2a,6a,8a,9ab)-Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one
Synonyms	INTERMEDIATE OF DOLASETRON 8-hydroxyhexahydro-2H-2,6-methanoquinolizin-3(4H)-one Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin(4H)-one (2α,6α,8α,9αβ)-Hexahydro-8-hydroxy-2,6-methano-2H-quinoliz ENDO-HEXAHYDRO-HYDROXY-2,6-METHANO-2H-QUINOLIZIN-3-(4H)-ONE Endo-Hexahydro-8-Hydroxy-2,6-Methano-2h-Quinolizin-3(4h)-One (6R,8R,9aS)-8-hydroxyhexahydro-2H-2,6-methanoquinolizin-3(4H)-one (2a,6a,8a,9ab)-Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one (2α, 6α, 8α, 9αβ) hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one (2A,6A,8A,9AB)-, HEXAHYDRO-8-HYDROXY-, 2,6-METHANO-2H-QUINOLIZIN-3(4H)-ONE (2A,6A,8A,9AB)-,HEXAHYDRO-8-HYDROXY-,2,6-METHANO-2H-QUINOLIZIN-3(4H)-ONE(INTERMEDIATEOFDOLASETRON) (2a,6a,8a,9ab)-,hexahydro-8-hydroxy-,2,6-Methano-2H-quinolizin-3(4H)-one (intermediate of dolasetron)
CAS	115956-07-5
InChI	InChI=1/C10H15NO2/c12-9-3-7-1-6-2-8(4-9)11(7)5-10(6)13/h6-9,12H,1-5H2/t6?,7-,8+,9+

内-六氢-8-羟基-2,6-亚甲基-2H-喹嗪-3(4H)-酮 - Physico-chemical Properties

Molecular Formula	C10H15NO2
Molar Mass	181.23
Density	1.28
Boling Point	356°C
Flash Point	169°C
Vapor Presure	1.67E-06mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.589

内-六氢-8-羟基-2,6-亚甲基-2H-喹嗪-3(4H)-酮 - Introduction

endo-hexahydro-8-hydroxy-2, 6-methylene-2H-quinazin-3 (4H)-one (also known as 8-hydroxyquinazinone) is an organic compound. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
The endo-hexahydro-8-hydroxy-2, 6-methylene-2H-quinazin-3 (4H)-one is a white crystalline solid with a bitter taste. Its chemical formula is C10H12N2O2 and its molecular weight is 188.21g/mol. The melting point of this compound is about 230-236 degrees Celsius, and its solubility is low. This compound is soluble in alcohol and ketone solvents.

Use:
endo-hexahydro-8-hydroxy-2, 6-methylene-2H-quinazin-3 (4H)-one has certain applications in the field of medicine. It is an antioxidant that can be used to prevent oxidation of food and cosmetics and to extend their shelf life. In addition, it has some potential pharmacological activities such as anti-cancer and anti-virus, but more research and experimental verification are needed.

Method:
The endo-hexahydro-8-hydroxy-2, 6-methylene-2H-quinazin-3 (4H)-one is usually obtained by chemical synthesis. A common preparation method is to react quinazinedione with sodium borohydride, followed by acid hydrolysis to finally obtain the target product.

Safety Information:
endo-hexahydro-8-hydroxy-2, 6-methylene-2H-quinazin-3 (4H)-one is generally relatively safe under normal use. However, contact with skin and eyes should be avoided. In case of accidental contact, rinse immediately with plenty of water and seek medical help in time. In addition, when using or storing the compound, the corresponding safety procedures should be observed, and the fire source and the inhalation of dust or gas should be avoided.

Last Update：2024-04-09 20:52:54