Name | quinine sulphate |
Synonyms | legatrin QUININE SULFATE Quinine sulfate quinine sulphate QUININE BISULFATE QUININE HEMISULFATE quininehydrogensulfate |
CAS | 804-63-7 |
EINECS | 212-359-2 |
InChI | InChI=1/2C20H24N2O2.H2O4S/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t2*13-,14-,19-,20+;/m00./s1 |
Molecular Formula | C40H50N4O8S |
Molar Mass | 746.91 |
Density | 1.0807 (rough estimate) |
Melting Point | 235.2°C |
Boling Point | 911.6°C at 760 mmHg |
Flash Point | 505.1°C |
Solubility | Soluble in ethanol, slightly soluble in water |
Vapor Presure | 0mmHg at 25°C |
Appearance | Pure white needle-like crystal |
Storage Condition | 2-8℃ |
Refractive Index | 1.6000 (estimate) |
MDL | MFCD00078499 |
Physical and Chemical Properties | Pure white needle-like crystalline, generally dull, can be made into a bright and compressible substance. It darkens brown when exposed to light. Odorless, with a strong, lasting bitterness. Saturated liquid litmus test is neutral or slightly alkaline. The melting point is 205 ℃, and the crystal water is lost when heated to 100 ℃. Optical rotation [α]D25 ℃-240 ~-248 (200mg dissolved in 0.1mol/L hydrochloric acid 10ml). Soluble in hot water (1:35) and ethanol (1:125), hardly soluble in chloroform and ether, but largely soluble in 1:2(V/V) chloroform-ethanol mixture. |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | 1544 |
HS Code | 29339900 |
Hazard Class | 6.1(b) |
Packing Group | III |
Reference Show more | 1. Song Xuemei, Zhang Yan, Yang Min, Liang Qi. Isolation and characterization of bitter peptides from hard cheese of yak milk [J]. Food Science, 2016,37(15):160-164. 2. Lizhen Liu, Zhi Mi, Ziying Guo, Junling Wang, Feng Feng,A label-free fluorescent sensor based on carbon quantum dots with enhanced sensing for the determination of myricetin real in samples, microchemical Journal,Volume 157,2020,104956,ISSN 0026-265 3. Liao, Ya, et al. "Basic taste characteristics of flavor material from cultured Takifugu." Flavour and Fragrance Journal 35.3 (2020): 320-328.https://doi.org/10.1002/ffj.3565 4. Pan Li, Yin Tian, Xiu-Mei Ke, Qing-Chu Tan, Xue Han, Hong-Yan Ma, Jin Pei, Jun-Zhi Lin, Run-Chun Xu, Li Han, Ming Yang, and Ding-Kun ZhangMolecular Pharmaceutics 2020 17 (5), 1586-1595DOI: 10.1021/acs.molpharmaceut.9b01296 5. [IF=11.413] Xue Han et al."A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle."Acta Pharm Sin B. 2018 Mar;8:209 6. [IF=5.279] Ninglong Zhang et al."Sensory-Guided Analysis of Key Taste-Active Compounds in Pufferfish (Takifugu obscurus)."J Agr Food Chem. 2019;67(50):13809-13816 7. [IF=1.085] Xue Han et al."A Novel Quantitative Prediction Approach for Astringency Level of Herbs Based on an Electronic Tongue."Pharmacogn Mag. 2017 Jul-Sep; 13(51): 492-497 8. [IF=7.514] Ninglong Zhang et al."Taste and stability characteristics of two key umami peptides from pufferfish (Takifugu obscurus)."Food Chem. 2022 Mar;371:131124 9. [IF=4.952] Ninglong Zhang et al."A potential flavor seasoning from aquaculture by-products: An example of Takifugu obscurus."Lwt Food Sci Technol. 2021 Nov;151:112160 10. [IF=4.939] Pan Li et al."Amphiphilic Block Copolymers: A Novel Substance for Bitter-Masking in Aqueous Solutions."Mol Pharmaceut. 2020;17(5):1586-1595 11. [IF=4.821] Lizhen Liu et al."A label-free fluorescent sensor based on carbon quantum dots with enhanced sensitive for the determination of myricetin in real samples."Microchem J. 2020 Sep;157:104956 12. [IF=4.142] Song Tianqun et al."One-step hydrothermal synthesis of WS2 quantum dots as fluorescent sensor for sensitive and selective recognition of hemoglobin and cardiac biomarker myoglobin."Anal Bioanal Chem. 2022 Feb;414(4):1623-1630 |
Quinine sulfate is a colorless crystalline powder.
Nature:
Including strong solubility, easy moisture absorption, stability in air, and stability at room temperature.
Method:
The production method of quinine sulfate usually involves reacting quinine with sulfuric acid to obtain it. Firstly, emulsify and extract quinine with sodium carbonate, then add dilute phosphoric acid to produce precipitate, and finally react with concentrated sulfuric acid to obtain quinine sulfate.
Security information:
1. Try to avoid inhaling its powder and avoid direct contact with the skin and eyes to avoid irritation.
2. Attention should be paid to the use of protective measures, such as wearing gloves and goggles, and maintaining a well ventilated working environment.
3. If accidentally exposed to quinine sulfate, rinse immediately with plenty of water and seek medical attention promptly.