孕甾-4-烯-17α,21-二醇-3,20-二酮-21-醋酸酯

Name	reichstein'S substance S 21-acetate
Synonyms	11-Deoxycortisol 21-acetate 17α-Hydroxycortexone 21-acetate 17-Hydroxy-21-acetoxyprogesterone reichstein'S substance S 21-acetate REICHSTEIN'S SUBSTANCE S 21-ACETATE REICHSTEIN'S COMPOUND ''S'' ACETATE RSA,REICHSTEIN'S SUBSTANCE S 21-ACETATE 17α,21-Dihydroxyprogesterone 21-acetate 17a-Hydroxy Progesterone-21-Acetate(RSA) 4-Pregnene-17α,21-diol-3,20-dione 21-acetate 17-hydroxy-3,20-dioxopregn-4-en-21-yl acetate 17,21-Dihydroxypregn-4-ene-3,20-dione21-acetate Corticosterone,11-deoxy-17-hydroxy-, 21-acetate 17,21-Dihydroxypregn-4-ene-3,20-dione 21-acetate Pregn-4-ene-3,20-dione,17,21-dihydroxy-, 21-acetate 17-alpha,21-dihydroxypregn-4-ene-3,20-dione 21-acetate
CAS	640-87-9
EINECS	211-369-4
InChI	InChI=1/C23H32O5/c1-14(24)28-13-20(26)23(27)11-8-19-17-5-4-15-12-16(25)6-9-21(15,2)18(17)7-10-22(19,23)3/h12,17-19,27H,4-11,13H2,1-3H3

Molecular Formula	C23H32O5
Molar Mass	388.5
Density	1.4 g/cm3
Melting Point	233-235°C
Boling Point	537.9±50.0 °C(Predicted)
Flash Point	181.8°C
Solubility	Chloroform (Sparingly), Methanol (Slightly, Heated)
Vapor Presure	8.2E-14mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	12.59±0.60(Predicted)
Storage Condition	Refrigerator
Refractive Index	1.558
Physical and Chemical Properties	Needle-like crystals (acetone). Melting point 237.2-240.2 °c.

Use	an intermediate of hydrocortisone.
production method	available diosgenin via ring opening, acylation, oxidation, hydrolysis, epoxidation, oxidation, (HBr) addition (introduction of bromine at 16-position), catalytic hydrogenation (debromination), 21-iodination, substitution of iodine at 21-position with acetyloxy, etc.

Last Update：2024-04-09 02:00:10