异紫堇定碱
isocorydine
CAS: 475-67-2
Molecular Formula: C20H23NO4
异紫堇定碱 - Names and Identifiers
异紫堇定碱 - Physico-chemical Properties
| Molecular Formula | C20H23NO4 |
| Molar Mass | 341.4 |
| Density | 1.2064 (rough estimate) |
| Melting Point | 216-220°C(lit.) |
| Boling Point | 477.03°C (rough estimate) |
| Specific Rotation(α) | D20 +195° (chloroform) |
| Flash Point | 259.9°C |
| Solubility | Slightly soluble in n-hexane |
| Vapor Presure | 7.29E-11mmHg at 25°C |
| Appearance | White powder |
| pKa | 9.41±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.5614 (estimate) |
| MDL | MFCD00075905 |
| Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the ground, Papaveraceae plant tuber Corydalis tuberosa DC. |
异紫堇定碱 - Risk and Safety
| WGK Germany | 3 |
| RTECS | CE1057950 |
| Toxicity | LD50 intraperitoneal in mouse: 104mg/kg |
异紫堇定碱 - Reference
| Reference Show more | 1. Yang, Zhenzhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).https://doi.org/10.1016/ |
异紫堇定碱 - Reference Information
| Overview | Isocorydine is also known as isocorydine, dextrorycorydine, and isocorydine, belonging to aporphine alkaloids. Aporphine alkaloids are a large class of alkaloids that are widely distributed in nature and have important biological activities. They are widely found in Magnoliaceae, Fanghexiaceae, Euphorbiaceae, Lambiaceae, and Berberis. Among plants such as the family, Ranunculaceae, Rutaceae, there are currently more than 400 aporphine alkaloids isolated from nature. Aporphine alkaloids have a wide range of pharmacological activities, such as anti-platelet aggregation activity (universal, receptor blocking activity (Nandinozine, Nandinozine) receptor blocking activity (Nandinozine, Corydalis, Magnolia Alkaline), arch ion channel blocking activity (Polidine base, sea medicine millet base, azopine antioxidant activity (Corydalis base, central inhibitory activity (Corydalis base, Corydalis block cap base, lotus leaf base, etc. |
| application | dextropicaldine has many pharmacological effects such as relieving epidemic, relaxing blood vessels, resisting diseases and resisting arrhythmia. As early as the century, some scholars have carried out research on the biological activity of dextropicaldine. In the year, the pharmacological experiments of dextropicaldine were carried out in animals such as babies, mice, rabbits, cats, and dogs. The results showed that the intensity of the action of dextropicaldine was related to the drug volume and species. For frogs and mice, the pharmacological effect of small sword volume is very weak, and a large amount can cause convulsions; for cats and dogs, the medium sword volume produces rigid fainting, and the large sword volume leads to hyperactivity. In the last century, through a large number of experiments, it was found that dextrocorydine has an effect on guinea pig ileum, vas deferens, common bile duct, gallbladder, sub-official, biliary sphincter, rabbit duodenum, biliary sphincter, aorta, portal vein, bovine coronary artery strips, mouse vas deferens and rat uterus and other species of isolated visceral smooth muscle has a non-specific pine pool effect, spasmolytic strength is close to the millet base. |
| Biological activity | The Isocorydine is isolated from the Dicranostigma leptopodum (Maxim.) Fedde. The combination of Isocorydine and doxorubicin (DOX) has the potential to eliminate hepatocellular carcinoma (HCC). |
| Cell Line: | Huh-7, Hep-G2 , SNU-387, SNU-449 cells Huh-7, Hep-G2 , SNU-387, SNU-449 cells |
| Concentration: | 0-400 ug/ml |
| Incubation Time: | 24 hours 24 hours |
| Result: | Had a higher cytotoxicity in HCC cells in comparison to ICD or DOX alone. Downregulated protein levels of Claundin-1 and E-cadherin. Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC. |
| Animal Model: | Female nude mice |
| Dosage: | 0.4 mg/ml |
| Administration: | Injected intraperitoneally every 2 days for 2 weeks |
| Use | Icorydine has anti-arrhythmia, vasodilator, and anti-hypoxia effects. |
Last Update：2024-04-10 22:29:15
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