白屈菜
CAS: 99-32-1
Molecular Formula: C7H4O6
白屈菜 - Names and Identifiers
| Synonyms | compoundxi* Greater Calandine Herb 4-Pyranone-2,6-dicarboxylic acid 4-Oxopyran-2,6-dicarboxylic acid 4-ketopyran-2,6-dicarboxylic acid 4H-Pyran-2,6-dicarboxylic acid, 4-oxo- Chelidonic acid,4-Oxo-4H-pyran-2,6-dicarboxylic acid |
| CAS | 99-32-1 |
| EINECS | 202-749-0 |
| InChIKey | PBAYDYUZOSNJGU-UHFFFAOYSA-N |
白屈菜 - Physico-chemical Properties
| Molecular Formula | C7H4O6 |
| Molar Mass | 184.1 |
| Density | 1.4880 (rough estimate) |
| Melting Point | 265 °C (dec.) (lit.) |
| Boling Point | 238.02°C (rough estimate) |
| Water Solubility | 14.3g/L(25 ºC) |
| Appearance | neat |
| Merck | 13,2060 |
| BRN | 163607 |
| pKa | 1.26±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5600 (estimate) |
| Physical and Chemical Properties | White crystalline powder. Decomposition at 257 ℃. 1g of the product can be dissolved in 65ml of water and 26ml of boiling water, which is hardly soluble in alcohol. |
| In vitro study | Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM. Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K i of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P. |
| In vivo study | Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice. |
白屈菜 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | UP7350000 |
| HS Code | 29329990 |
白屈菜 - Reference Information
| biological activity | cheliedonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) it is a secondary metabolite found in several plants and has therapeutic potential for allergic diseases in experimental animals. Celiac acid inhibited production by HMC-1 by blocking NF-κB and caspase-1 in IL-6 cells. Chillidonic acid is also an inhibitor of glutamate decarb oxylase with a Ki value of 1.2 μm. |
| Target | Value |
| Use | for organic synthesis. |
| production method | is obtained from the reaction of diethyl oxalate and acetone. |
Last Update：2024-04-09 15:16:55
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Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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Email: 3008007409@qq.com
Mobile: 18021002903
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View History
白屈菜
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柔软剂D3
4-咪唑乙酸盐酸盐
4-N-FMOC-四氢吡喃-4-甲酸
2-乙烯吡啶
3-氯丙基甲基砜
乙炔基氯化镁 0.5M IN THF
Perindoprilat (S-9780)
METHYL (3S)-3-AMINO-3-(2-METHOXYPHENYL)PROPANOATE HYDROCHLORIDE
CIS-3-CARBOMETHOXYCYCLOPENTANE-1-CARBOXYLIC ACID
柔软剂D3
4-咪唑乙酸盐酸盐