磺胺醋酰
N-Sulfanilylacetamide
CAS: 144-80-9
Molecular Formula: C8H10N2O3S
磺胺醋酰 - Names and Identifiers
| Name | N-Sulfanilylacetamide |
| Synonyms | A-500 Sulfacetamide Sulphacetamide N-Sulfanilylacetamide LABOTEST-BB LT00053160 N-sulphanilylacetamide sulfacetamide free base n(sup1)-acetyl-sulfanilamid N(Sup1)-Acetylsulfanilamide 1-acetylpyrrolidine-2,5-dione N1-Acetyl-4-aminophenylsulfonamide N-(4-Aminophenylsulphonyl)acetamide N-[(p-Aminophenyl)sulfonyl]acetamide N-(4-Aminobenzenesulphonyl)acetamide n-[(4-aminophenyl)sulfonyl]-acetamid |
| CAS | 144-80-9 |
| EINECS | 205-640-6 |
| InChI | InChI=1/C6H7NO3/c1-4(8)7-5(9)2-3-6(7)10/h2-3H2,1H3 |
| InChIKey | SKIVFJLNDNKQPD-UHFFFAOYSA-N |
磺胺醋酰 - Physico-chemical Properties
| Molecular Formula | C8H10N2O3S |
| Molar Mass | 214.24 |
| Density | 1.3844 (rough estimate) |
| Melting Point | 182-184°C |
| Boling Point | 239.433°C at 760 mmHg |
| Flash Point | 107.073°C |
| Solubility | Soluble in ethanol, slightly soluble in water or ether, almost insoluble in chloroform or benzene, soluble in dilute mineral acid or alkali hydroxide solution. |
| Vapor Presure | 0.04mmHg at 25°C |
| Appearance | White to pale yellow crystalline powder |
| Color | white to off-white |
| Merck | 14,8899 |
| BRN | 981718 |
| pKa | pKa 1.76±0.04(H2Ot = 25I = 0.15 (KCl)Ar atmosphere)(Approximate);5.22±0.01(H2Ot = 25I = 0.15 (KCl)Ar |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids. |
| Refractive Index | 1.5690 (estimate) |
| MDL | MFCD00066501 |
| Physical and Chemical Properties | Appearance: white powder Melting Point: 182 - 184 water-soluble:<0.01g/100 mL at 16 C
|
| Use | Mainly used for the treatment of conjunctivitis, trachoma and other eye infections and other diseases |
磺胺醋酰 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | AC8450000 |
| TSCA | Yes |
| HS Code | 29350090 |
| Toxicity | LD50 orally in dogs: 8000 mg/kg (Fisher) |
磺胺醋酰 - Reference
| Reference Show more | 1. [IF=5.833] Hu Wenyao et al."Flexible membrane composite based on sepiolite/chitosan/(silver nanoparticles) for enrichment and surface-enhanced Raman scattering determination of sulfamethoxazole in animal-derived food."MICROCHIMICA ACTA. 2022 May;189(5):1-12 |
磺胺醋酰 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Sulfacetamide (Sulphacetamide) is an antibacterial sulfanilamide, a commonly used antibiotic, and has the potential to be used in the study of eye infections. |
| use | medicine for the treatment of conjunctivitis, trachoma and other eye infections. Mainly used to treat conjunctivitis, trachoma and other eye infections and other diseases Sulfonamides are used to treat infections caused by bacteria. |
| production method | sodium sulfacetamide is acidified, sodium sulfamethoxide is dissolved in water, adjusted to pH3.8-4 with 5% hydrochloric acid, and sulfamethamide is precipitated. Filter, wash and dry to obtain the finished product. |
Last Update：2024-04-09 21:01:54
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