脑硫
bornan-2-one
CAS: 76-22-2
Molecular Formula: C10H16O
脑硫 - Names and Identifiers
| Name | bornan-2-one |
| Synonyms | Camphor 2-Bornanone bornan-2-one Synthetic Camphor Camphor synthetic plus-minus-camphor CAMPHOR TECH. GRADE Camphor Natural,Tablet CAMPHOR SYNTHETIC FLAKES CAMPHOR SYNTHETIC POWDER 1,7,7-trimethyl-norcampho CAMPHOR SQUARES SYNTHETIC TECHNICAL 1,7,7-trimethyl-bicyclo(2.2.1)heptan-2-on 1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-on 1,7,7-trimethylbicyclo[2.2.1]-2-heptanone (camphor) |
| CAS | 76-22-2 |
| EINECS | 200-945-0 |
| InChI | InChI=1/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3 |
| InChIKey | DSSYKIVIOFKYAU-MHPPCMCBSA-N |
脑硫 - Physico-chemical Properties
| Molecular Formula | C10H16O |
| Molar Mass | 152.23 |
| Density | 0.992 |
| Melting Point | 175-177°C(lit.) |
| Boling Point | 204°C(lit.) |
| Flash Point | 148°F |
| JECFA Number | 2199 |
| Water Solubility | 0.12 g/100 mL (25 ºC) |
| Solubility | Soluble in acetone, ethanol, diethylether, chloroform and acetic acid. |
| Vapor Presure | 4 mm Hg ( 70 °C) |
| Vapor Density | 5.2 (vs air) |
| Appearance | neat |
| Color | White or Colorless |
| Exposure Limit | TLV-TWA 12 mg/m3 (2 ppm), STEL 18mg/m3 (3 ppm) (ACGIH); IDLH 200 mg/m3(NIOSH).. |
| Merck | 14,1732 |
| BRN | 1907611 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics. |
| Explosive Limit | 0.6-4.5%(V) |
| Refractive Index | 1.5462 (estimate) |
| Physical and Chemical Properties | Characteristics colorless or white crystals, granular or easily broken block. There is a pungent aroma. Volatilize slowly at room temperature. melting point 179.75 ℃ boiling point 204 ℃ freezing point relative density 0.99g/cm3 refractive index flash point 65.6 ℃ solubility soluble in water, soluble in ethanol, ether, chloroform, carbon disulfide, solvent naphtha and volatile or non-volatile oils. |
| Use | Widely used in medicine, plastic industry and daily life in the anti-insect, anti-cavity, anti-odor |
脑硫 - Risk and Safety
| Risk Codes | R11 - Highly Flammable R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2717 4.1/PG 3 |
| WGK Germany | 1 |
| RTECS | EX1225000 |
| TSCA | Yes |
| HS Code | 29142910 |
| Hazard Class | 4.1 |
| Packing Group | III |
| Toxicity | LD50 orally in mice: 1.3 g/kg (PB293505) |
脑硫 - Upstream Downstream Industry
脑硫 - Nature
Open Data Verified Data
colorless or white crystals, granular or easily broken blocks. Flammable. Toxic. There is a pungent aroma. Volatilize slowly at room temperature. Micro-soluble in water, soluble in ethanol, ether, chloroform, carbon disulfide, solvent naphtha and volatile or non-volatile oils. Density: 0.99g/m3. Melting point 179.75 °c. Boiling Point 204 °c (sublimation). Flash point (closed cup) 65.6 °c. Spontaneous ignition point 466. The explosion limit in air is 0.6% ~ 3.5%. Chemical stability. Camphoric acid is generated during mild oxidation. Borneol was generated during reduction.
Last Update：2024-01-02 23:10:35
脑硫 - Preparation Method
Open Data Verified Data
- camphor oil purification method camphor root, dry, branch cut into wood chips for steam distillation to obtain camphor oil, vacuum distillation, freezing, centrifugation, sublimation, preparation of refined products.
- synthesis of turpentine as raw material, from which the extraction of pinene, by isomerization of pinene. Then it is esterified with acetic acid to produce isobornyl acetate, and then hydrolyzed by saponification to obtain isoborneol. Finally, it is dehydrogenated, distilled and sublimed to obtain synthetic camphor.
Last Update：2022-01-01 10:38:48
脑硫 - Use
Open Data Verified Data
This product is used in the pharmaceutical industry to prepare anti-cavity drugs for cardiotonic agents, stimulants, coolants, antipruritic agents, clothes and books. Plasticizers which are also used in the preparation of esters and ethers of celluloid and cellulose. This plasticizer can improve the transparency and toughness of polyvinyl chloride. It is also used for the preparation of fireworks, pesticides, explosive stabilizers and paints.
Last Update：2022-01-01 10:38:47
脑硫 - Safety
Open Data Verified Data
- This product has moderate toxicity, and its vapor can kill insects, sparrows and other birds, at a concentration of 200 x 10-6 (1. 3mg/L) under the steam, the mice inhaled 5~10 minutes will jump restless, Dyspnea, dizziness, intense spasm, then stop breathing and death. It can damage the heart function of rabbits, and its toxicity is much greater than that of chloroform. Camphor vapor on the human body can also cause heart dysfunction, will make people appear lethargy, Dyspnea, the muscle paralysis and death. The lowest lethal dose of subcutaneous injection in rats was 2.2g/kg. The maximum allowable concentration in the workplace is 2mg/m3.
- production equipment should be sealed to prevent leakage, and operators should wear protective masks. Good ventilation was maintained at the production site. It is packed in plastic bag, carton, or linen bag or wooden box. 25kg or 50kg per bag. Store in a cool, ventilated place, away from fire. During the transport to fire, heat.
Last Update：2022-01-01 10:38:48
脑硫 - Compound camphor tincture
Authoritative Data Verified Data
This product contains morphine (C17H19N03) per lml should be 0.425 ~ 0.575mg.
prescription
camphor 3G
Opium Tincture
Benzoic acid 5G
Star anise oil 3ml
Ethanol (56%) appropriate amount
Made up to 1000ml
preparation method
add benzoic acid, camphor and star anise oil, add 56% ethanol to dissolve, slowly add the appropriate amount of Opium Tincture and 56% ethanol, make the whole amount to 1000ml, stir and filter to obtain.
trait
This product is yellow-brown liquid; There are camphor and star anise oil aroma.
identification
take 2ml of this product, add ammonia solution to adjust the pH value to about 9; Add chloroform-Isopropanol (3:1) to extract 2 times, each time the amount of 20ml, combined extract, filtered through anhydrous sodium sulfate, the filtrate was evaporated to dryness under reduced pressure, and the residue was dissolved by adding 0.3ml of methanol as a test solution. An appropriate amount of morphine control was taken, dissolved and diluted with methanol to prepare a solution containing about 1 mg per 1 ml, as a control solution. According to the thin layer chromatography (General 0502) test, take the above two Solutions 10 u1, respectively, on the same silica gel G thin layer plate, with ethyl acetate-methanol-concentrated ammonia solution (17:2:1) for the development of the agent, expand, dry, spray with dilute bismuth potassium iodide solution. The spot position and color of the test solution should be consistent with the spot position and color of the morphine control solution.
examination
- the amount of ethanol should be 52% to 60% (General 0711 gas chromatography).
- others should comply with the relevant provisions under tincture (General rule 0120).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using octyl silane bonded silica gel as filler; 0.05mol/L potassium dihydrogen phosphate solution -0.0025mol/L sodium heptane sulfonate aqueous solution-acetonitrile (2:2:1) as mobile phase; The detection wavelength was 220nm. The number of theoretical plates was not less than 1000 based on the morphine peak.
- suitability test of solid phase extraction column system a silica gel bonded with a Eighteen alkyl silane was used as a filler; The same treatment conditions and elution conditions in the measurement method were tested. Accurately measure 1ml of 5% acetic acid solution containing 0.25mg morphine reference substance per 1ml, set on the treated same-phase extraction column, elute with the same method, and collect the eluate with 5ml measuring flask to the scale, shake well as a system-suitable solution. The suitable solution of the system and the reference solution under the content determination item are respectively 10 u1 and injected into the human liquid chromatograph to record the chromatogram.
- one homogenous extraction column was used for the determination, washed with methanol water (3:1)l5ml and water 5ml successively, and then with ammonia solution with pH value of about 9 (the water was suitable for children, the ammonia test solution was added dropwise until the pH value was 9) and the effluent was flushed until the pH value of the effluent was about 9, which was to be used. Take 1 bottle of this product, ultrasonic 10 minutes, take out and shake; Precision take 5ml, put the grinding mouth conical flask, steam dry, precision plus 5% acetic acid solution 10ml, ultrasonic 10 minutes to dissolve morphine, take out, cool and filter; Take 1ml of the continuous filtrate accurately, place it on the above solid phase column, and add appropriate amount of ammonia test solution Dropwise to make the pH value of the solution in the column about 9. Take the same volume of continued filtrate before sample, to determine the amount of dropping ammonia solution), shake, after the solvent drops, rinse with about 20ml of water, elute with 5% acetic acid solution containing 20% methanol, collect the eluate with 5ml measuring flask to the scale, shake well, precisely take LOL and inject it into human liquid chromatograph, record chromatogram; Take morphine reference substance, add 5% acetic acid solution containing 20% methanol to dissolve and quantitatively dilute to make a solution containing about 0.05mg morphine per 1ml. According to the external standard method, the peak area of morphine was calculated.
category
antitussive, analgesic, antidiarrheal.
storage
shade, seal, and store in a cool and dry place.
Last Update：2022-01-01 13:43:51
脑硫 - Reference Information
| FEMA | 4513 | dl-CAMPHOR |
| Henry's Law Constant | (x 10-5 atm?m3/mol):3.00 at 20 °C (approximate - calculated from water solubility and vapor pressure) |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | camphor is colorless to white translucent block or powder, has camphor odor, and is widely used. Camphor is used as a nerve stimulant and a local stimulant in medicine, and can be used for cooling and cooling drugs such as Ten drops of water and man Dan. It can also be used for the preparation of food essences such as mint, lime and nuts, and the preparation of toilet water, daily cosmetics and other daily flavors. In addition, camphor is used in a large amount in selolu and photographic films, as a stabilizer for manufacturing smokeless powder, as a raw material for manufacturing sodium camphor sulfonate, and the like. |
| uses | is an important pharmaceutical and chemical raw materials, can be used as plasticizers, used in the production of plastics, false Ivors, varnishes, explosives, insect repellents, preservatives, etc. used as pharmaceutical intermediates used in the production of celluloid, film, artificial ivory, Essence, etc., also used in the production of rubber, electrical insulation materials, aircraft parts, etc; it can also be used as an explosion stabilizer for smokeless powder made in the arms industry, pesticides made in the pesticide industry, and anti-cavity drugs for stimulants, cardiotonic agents, ten drops of water, coolants, antipruritic agents, clothing and books formulated in the pharmaceutical industry, preservatives, etc. It is widely used in medicine, plastic industry and daily life to prevent insects, moths and odour It is used in pharmaceutical industry and determination of molecular weight by Lai's method, also used as reference samples for pesticide microanalysis and gas chromatography. Cellulose esters and ethers of plasticizers, explosives, pyrotechnic, insecticides, manufactured celluloid. |
| production method | 1. Camphor oil purification method camphor exists in the camphor tree, take the camphor tree dry, root, branch, leaf by steam distillation of camphor oil, the vacuum fractionation of oil camphor and various essential oils, oil camphor is purified by sublimation to obtain refined camphor. Synthesis of turpentine as raw material, extraction of the pinene, by isomerization of Carene, then by esterification, hydrolysis, dehydrogenation and camphor. The esterification reaction may be carried out in a glass-lined reaction pot. Under the catalysis of sulfuric acid, the esterification of pinene with acetic acid or formic acid is carried out at a reaction temperature of 38 ° C., the reaction temperature is maintained at 45-48 ° C. When sulfuric acid is added, and the time of dropwise addition of sulfuric acid is 2-3H. After completion of the reaction, 40% liquid alkali was added and reacted at 140 ° C. Under 0.2-0.25MPa for 6-8H to obtain isoborneol. After dissolving xylene and washing with water, the reaction is converted into camphor by dehydrogenation under the action of basic copper carbonate, and the reaction is carried out in slight alkalinity by adding an appropriate amount of slaked lime. The crude camphor obtained by dehydrogenation was purified by sublimation to obtain synthetic camphor. According to GB 4895-85, the first grade camphor content is greater than or equal to 96%, the melting point of 174. Raw material consumption quota: turpentine 1700kg/t, acetic acid 600kg/t. |
| category | flammable solid |
| toxicity grade | poisoning |
| Acute toxicity | oral-mouse LD50: 1310 mg/kg; Intraperitoneal-rat LDL0: 900 mg/kg |
| explosive hazard characteristics | in case of heat, open flame, CRO3 and other oxidant vapor can be exploded |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| fire extinguishing agent | foam, carbon dioxide, dry powder |
| Occupational Standard | TWA 13 mg/m3; Tel 20 mg/m3 |
| spontaneous combustion temperature | 870 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-threatening and health concentration | 200 mg/m3 |
Last Update：2024-06-11 15:32:48
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