阿利吉仑中间体SP-4

阿利吉仑中间体SP-4 - Names and Identifiers

Name	[(1S,3S)-3-[[4-Methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methyl-1-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic acid tert-butyl ester
Synonyms	tert-butyl InterMediate of Aliskiren tert-Butyl ((1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-4-Methylpentyl)carbaMate [(1S,3S)-3-[[4-Methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methyl-1-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic acid tert-butyl ester [(1S,3S)-3-[[4-Methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methyl-1-[(2S, 4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic Acid 1,1-tert-Butyl Ester N-[(1S,3S)-3-[[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methyl-1-[(2S, 4S)-tetrahydro-4-(1-Methylethyl)-5-oxo-2-furanyl]pentyl]carbaMic Acid 1,1-DiMethylethyl Ester [(1S,3S)-3-[[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methyl-1-[(2S,4S)-tetrahydro-4-(1-Methylethyl)-5-oxo-2-furanyl]pentyl]-, 1,1-diMethylethyl ester CarbaMic acid CarbaMic acid, [(1S,3S)-3-[[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methyl-1-[(2S,4S)-tetrahydro-4-(1-Methylethyl)-5-oxo-2-furanyl]pentyl]-, 1,1-diMethylethyl ester Carbamic acid, [(1S,3S)-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methyl-1- [(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]-, 1,1-dimethylethyl ester 1,1-Dimethylethyl[(1S,3S)-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl] methyl]-4-methyl-1-[((2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic Acid 1,1-tert-Butyl Ester
CAS	866030-35-5

阿利吉仑中间体SP-4 - Physico-chemical Properties

Molecular Formula	C30H49NO7
Molar Mass	535.71
Density	1.057
Boling Point	650.4±50.0 °C(Predicted)
Solubility	Dichloromethane, Methanol
pKa	11.81±0.46(Predicted)
Storage Condition	2-8°C

阿利吉仑中间体SP-4 - Introduction

[(1S,3S)-3-[[4-Methoxy-3-(3-methoxyproxy) phenyl]methyl]-4-methyl-1-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic acid tert-butyl ester, also known as [(1S,3S)-3-[[4-Methoxy-3-(3-methoxyproxy) phenyl]methyl]-4-methyl-1-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic acid tert-butyl ester, an organic compound.

Properties of the compound:
Appearance: A colorless liquid
Molecular formula: C27H41NO6
Molecular weight: 483.62g/mol
Melting point: irreversible stability <25°C
Boiling point: 467.3±45.0°C (predicted)
Flash Point: 234.2±28.7°C (predicted)
Density: 1.0±0.1g/cm3 (predicted)

Application:
[(1S,3S)-3-[[4-Methy-3-(3-methoxyproxy) phenyl]methyl]-4-methyl-1-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic acid tert-butyl are widely used as anti-inflammatory drugs and immunomodulators.

Preparation Method:
The compound can be obtained by synthetic route and chemical reaction, specific steps can refer to the relevant literature or patent.

Safety Information:
[(1S,3S)-3-[[4-Methy-3-(3-methoxyproxy) phenyl]methyl]-4-methyl-1-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamic acid tert-butyl ester may cause irritation to human body and eye safety before use, so be careful. Specific safety information, such as toxicity data, hazardous material markings and personal protective measures, can be found in the relevant chemical safety information. When using, please follow the correct laboratory operating procedures, take adequate ventilation and personal protective measures, such as wearing laboratory gloves, eye protection and breathing equipment.

Last Update：2024-04-09 20:49:11