((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
Molnupiravir
CAS: 2349386-89-4
Molecular Formula: C13H19N3O7
((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate - Names and Identifiers
| Name | Molnupiravir |
| Synonyms | Tube994 EIDO-2801 EIDD-2801 Molnupiravir EIDD-2801(EIDD 2801) Molnupiravir(MK-4482) Uridine, 4-oxime, 5'-(2-methylpropanoate) β-D-N4 hydroxycytidine-5'-isopropyl ester ((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate |
| CAS | 2349386-89-4 |
| EINECS | 604-604-1 |
((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate - Physico-chemical Properties
| Molecular Formula | C13H19N3O7 |
| Molar Mass | 329.31 |
| Density | 1.115±0.06 g/cm3(Predicted) |
| Melting Point | 156 - 159°C |
| Boling Point | 582.6±50.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | -20°C, Inert atmosphere |
| Use | It is a key intermediate in the preparation of Sacubitril |
((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate - Introduction
Molnupiravir (EIDD-2801) is an orally bioavailable isopropyl ester prodrug in the EIDD-1931 of a ribonucleoside analog. Molnupiravir show a wide range of activities against influenza viruses and coronaviruses such as SARS-CoV-2,MERS-CoV, and SARS-CoV. Molnupiravir have the potential for COVID-19 and seasonal, pandemic influenza.
Last Update：2023-08-16 23:22:23
((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate - biological activity
Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza
Last Update：2023-08-16 23:22:23
((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate - Vivo study
Molnupiravir (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease.
Molnupiravir (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever.
| Animal Model: | C57BL/6 mice (intranasal infection with SARS-CoV) |
| Dosage: | 50, 150, 500 mg/kg |
| Administration: | Oral; every 12 hours for 3 days |
| Result: | Body weight loss is significantly diminished or prevented. |
| Animal Model: | Ca/09-infected female ferrets |
| Dosage: | 7 mg/kg |
| Administration: | Oral; twice daily for 3.5 days |
| Result: | Shed virus load and duration of fever were significantly reduced. |
Last Update：2023-08-16 23:22:23
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CAS: 2349386-89-4
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
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Product Name: Molnupiravir Request for quotation
CAS: 2349386-89-4
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327Send QQ message
CAS: 2349386-89-4
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327
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((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
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