(+)-CORYDINE

Name	Corydine
Synonyms	Corydine d-Corydine d-corydine BRN 0095568 Glaucentrin glaucentrin glaucentrine (+)-CORYDINE Glaucentrine CORYDINE, (+)- (+)-CORYDALINE (S)-(+)-Corydine (s)-(+)-corydine O(sup 11)-Methylcorytuberine 2,10,11-trimethoxy-6a-alpha-aporphin-1-o 6a-alpha-Aporphin-1-ol, 2,10,11-trimethoxy- 5-21-06-00134 (Beilstein Handbook Reference) 4h-dibenzo(de,g)quinolin-1-ol,5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methy (6aS)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol 4H-Dibenzo(de,g)quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (S)-
CAS	476-69-7
InChI	InChI=1/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1

Molecular Formula	C20H23NO4
Molar Mass	341.4
Density	1.222±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	165-167℃
Boling Point	477.03°C (rough estimate)
Specific Rotation(α)	D20 +204° (c = 1.6 in chloroform)
Flash Point	259.7°C
Solubility	Very slightly soluble (0.72 g/L) (25 °C)
Vapor Presure	7.51E-11mmHg at 25°C
Appearance	Cryst.
Color	White to Off-White
pKa	9.68±0.20(Predicted)
Storage Condition	4°C, Inert atmosphere
Refractive Index	1.5614 (estimate)
MDL	MFCD00076020
Physical and Chemical Properties	Soluble in methanol, ethanol, DMSO and other organic solvents.

Toxicity

LD50 subcutaneous in mouse: 115mg/kg

biological activity	Corydine is a naturally occurring alkaloid that can be extracted from Croton echinocarpus leaves. Corydine effectively inhibited reverse transcriptase (reverse transcriptase,RT) activity with IC50 of 356.8 μg/mL. Corydinez has anti-HIV potential in vitro and inhibits 40% HIV-1 reverse transcriptase activity at a concentration of 450 μg/mL.
chemical properties	soluble in methanol, ethanol, DMSO and other organic solvents.
use	purinol has the functions of inhibiting bacteria, clearing away heat and toxic materials, killing insects and relieving itching.

Last Update：2024-04-10 22:29:15

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CAS: 476-69-7
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