(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Names and Identifiers

Name	alpha-Methyldopa sesquihydrate
Synonyms	DISCONTINUED alpha-Methyldopa sesquihydrate (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate
CAS	41372-08-1
EINECS	609-918-1

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Physico-chemical Properties

Molecular Formula	C10H13NO4·1·5H2O
Molar Mass	238.24
Melting Point	>300 °C(lit.)
Water Solubility	0.1-1 g/100 mL at 23 ºC
Appearance	Shape neat, color White to Off-White
Storage Condition	2-8°C
Stability	Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.
Physical and Chemical Properties	Bioactive Methyldopa hydrate (L-(-)-α-Methyldopa hydrate) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a prodrug that is metabolized in the central nervous system (α-Methyllepinephrine).
Use	Use L-Methyldopa is a beta-blocker cardiovascular drug that has a good effect on moderate-procedure primary and renal hypertension.

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Risk and Safety

Risk Codes	R20/21 - Harmful by inhalation and in contact with skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R65 - Harmful: May cause lung damage if swallowed
Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	YP2860000
FLUKA BRAND F CODES	10-23
HS Code	2922504500

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Improved Synthesis of L-methyldopa

from Wanfang

Author:

Wu Fan macro , tiny flowers , Yang Xueyan , shuhaiying , Zhou Weiguo

Abstract:

(3 ',4'-dimethoxyphenyl)-2-amino-2-methylpropionitrile was obtained from 3, 4-dimethoxyphenylacetone by Strecker reaction, L-(3 ',4'-dimethoxyphenyl)-2-amino-2-methylpropionitrile hydrochloride is then resolved with L-tartaric acid and hydrolyzed, demethylation gave the target product L-methyldopa in 50.4% yield.

Key words:

L-methyldopa 3, 4-dimethoxyphenylacetone Strecker reaction

DOI:

10.3969/j.issn.1001-9677.2008.02.015

cited:

year:

2008

Last Update：2024-01-02 23:10:35

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Preparation of L-methyl Methyl gallate

from Palm Bridge research

patent type:

invention patent

Application (patent) number:

CN201711461044.4

application date:

20171228

Public/Announcement Number:

CN108147974A

Public/announcement date:

20180612

applicant (patent):

Shandong Xinhua Pharmaceutical Co., Ltd.

inventor:

Wang Bing , Shen Ping , Yan Pei , Wang Yiyun , hole Blue , fan Chunwei , Wang Xichun , Wang Zhi

National and provincial code:

CN370303

Abstract:

The invention relates to a preparation process of L-methyl methanone, belonging to the field of organic chemical synthesis. The preparation process of L methyl methyl methyl ester comprises the following steps: 1. L methyl DOPA and methanol were added sequentially, and hydrogen chloride gas was introduced; 2. The esterification reaction took place at 045 °c for 1072 hours; 3. After completion of the esterification reaction, the product was obtained by filtration, dissolution, neutralization, crystallization, centrifugation and drying. The preparation process of the invention can improve the yield and reduce the energy consumption, and at the same time, the mother liquor can be recycled, the cost is reduced, and the environment is friendly.

Last Update：2023-08-16 22:09:08

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Spectroscopic data and structural confirmation of L-methyldopa

from hownet

Author:

Lou Yong-jun

Abstract:

Objective to confirm the structure of L-methyldopa. Methods ultraviolet, infrared, hydrogen spectrum, carbon spectrum and mass spectrum were used to analyze the structure. Results The maximum absorption peak was red-shifted in 0.1mol · L-1 sodium hydroxide solution. The infrared spectrum showed that the molecule contained hydroxyl, Amino, carbonyl and benzene ring; the molecular ion peak m/z of the mass spectrum was 211. Conclusion The structure of L-methyldopa can be confirmed by the above method.

Key words:

L-methyldopa Structure corroboration

DOI:

CNKI:SUN:XDYD.0.2009-S1-015

year:

2009

Last Update：2023-08-16 22:09:08

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: alpha-Methyldopa sesquihydrate Request for quotation
CAS: 41372-08-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: α-Methyl-L-DOPA Visit Supplier Webpage Request for quotation
CAS: 41372-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Hefei TNJ Chemical Industry Co.,Ltd.

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: α-Methyl-L-DOPA Visit Supplier Webpage Request for quotation
CAS: 41372-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate

alpha-Methyldopa sesquihydrate

CAS: 41372-08-1

Molecular Formula: C10H13NO4·1·5H2O

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Names and Identifiers

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Physico-chemical Properties

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Risk and Safety

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Improved Synthesis of L-methyldopa

from Wanfang

Author:

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Preparation of L-methyl Methyl gallate

from Palm Bridge research

patent type:

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Spectroscopic data and structural confirmation of L-methyldopa

from hownet

Author:

Supplier List

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate Request for Quotation

alpha-Methyldopa sesquihydrate

CAS: 41372-08-1

Molecular Formula: C10H13NO4·1·5H2O

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Names and Identifiers

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Physico-chemical Properties

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Risk and Safety

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Improved Synthesis of L-methyldopa

from Wanfang

Author:

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Preparation of L-methyl Methyl gallate

from Palm Bridge research

patent type:

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate - Spectroscopic data and structural confirmation of L-methyldopa

from hownet

Author:

Supplier List

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate