(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate

(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate - Names and Identifiers

Name	L-Cysteinesulfinic Acid, Monohydrate
Synonyms	3-sulfino-l-alanine Sulfino-L-alanine hydrate L-Cysteinesulfinic Acid (hydrate) (2R)-2-aMino-3-sulfinopropanoic acid L-Cysteinesulfinic Acid, Monohydrate (1R)-1-amino-2-mercaptoethanesulfinic acid hydrate
CAS	207121-48-0
EINECS	623-116-9

(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate - Physico-chemical Properties

Molecular Formula	HO2SCH2CH(NH2)CO2HH2O
Molar Mass	171.17
Melting Point	163°C (dec.)(lit.)
Boling Point	580.6℃ at 760 mmHg
Storage Condition	-20°C
Stability	Temperature Sensitive
In vitro study	L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC 50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing.

(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate - Reference Information

biological activity

L-Cysteinesulfinic acid monohydrate is an effective metabotropic glutamate receptor (mGluRs) agonist that acts on mGluR1,mGluR5,mGluR2,mGluR4,mGluR6 and mGluR8,pEC50 are 3.92,4.6,3.9,2.7,4.0, and 3.94, respectively.

Last Update：2024-04-09 20:49:11