(1R,2R)-(-)-1,2-Cyclohexanedicarboxylic Acid
(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid
CAS: 46022-05-3
Molecular Formula: C8H12O4
(1R,2R)-(-)-1,2-Cyclohexanedicarboxylic Acid - Names and Identifiers
(1R,2R)-(-)-1,2-Cyclohexanedicarboxylic Acid - Physico-chemical Properties
| Molecular Formula | C8H12O4 |
| Molar Mass | 172.18 |
| Density | 1.314±0.06 g/cm3(Predicted) |
| Melting Point | 184 °C |
| Boling Point | 384.1±35.0 °C(Predicted) |
| Solubility | Soluble in acetone. |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 4.18±0.28(Predicted) |
| Storage Condition | Store below +30°C. |
| Refractive Index | -18 ° (C=1, Acetone) |
| MDL | MFCD00062973 |
(1R,2R)-(-)-1,2-Cyclohexanedicarboxylic Acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | WGK 3 highly water e |
| HS Code | 29171900 |
(1R,2R)-(-)-1,2-Cyclohexanedicarboxylic Acid - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | (1R,2R)-1, 2-cyclohexanedicarboxylic acid is a key intermediate of lurasidone hydrochloride, which can be prepared by splitting trans-1, 2-cyclohexanedicarboxylic acid. Lurasidone hydrochloride is a new type of atypical antipsychotic drug developed by Sumitomo Pharmaceutical Company in Japan. It was first listed in the United States in 2010 and was approved by FDA for the treatment of adult schizophrenia and as a single drug/as a lithium salt or Valproic acid adjuvant therapy for bipolar I disorder-related depressive episodes in adult patients. In 2014, it was approved by EMA for listing in the European Union. It has a high binding force on dopamine D2 receptor and serotonin (5-HT1A, 5-HT2A, 5-HT7) and α2C receptor, and a small binding force on other receptors. It has significant curative effect on both positive and negative symptoms of psychiatric patients. Studies have reported that lurasidone can improve cognitive function, cause less weight gain, and do not cause glucose, lipid (lipid), ECG and QT interval changes. |
| Preparation | Using trans-1, 2-cyclohexanedicarboxylic acid as raw materials, 1R,2R-cyclohexanedicarboxylic acid is prepared by splitting; trans-1, 2-cyclohexanedioic acid and R-( )-α-phenethylamine react into salt at a temperature of 5 ℃, filter and dry at room temperature; then in hot ethanol/toluene (1:1) Recrystallization once in mixed solvent, finally adding hydrochloric acid free, and extracting with ether to obtain ((1R,2R)-1, 2-cyclohexanedicarboxylic acid. |
Last Update：2024-04-09 20:52:54
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