(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine
CAS: 758691-50-8
Molecular Formula: C16 H20 N2 O2
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine - Names and Identifiers
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine - Physico-chemical Properties
| Molecular Formula | C16 H20 N2 O2 |
| Molar Mass | 272.34 |
| Density | 1.135±0.06 g/cm3(Predicted) |
| Boling Point | 441.4±45.0 °C(Predicted) |
| pKa | 9.91±0.10(Predicted) |
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine - Introduction
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine is an organic compound with the chemical structure of C18H22N2O2.
Nature:
-Appearance: colorless or light yellow liquid
-Melting point: about 15-19 degrees Celsius
-Boiling point: about 446-448 degrees Celsius
-Density: approx. 1.096g/cm3
-Solubility: Soluble in organic solvents such as ethanol, dimethylformamide and dimethyl sulfoxide.
Use:
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine are often used as chiral catalysts in organic synthesis reactions. It can participate in various reactions including asymmetric reduction, cyclization, arylation, etc.
Preparation Method:
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine can be synthesized in many ways. One of the common methods is to reduce the diphenyl sulfoxide on the chiral meta nitrogen. The specific steps are as follows:
1. the reaction of benzaldehyde and methanol to generate benzyl methanol.
2. the reaction of benzyl methanol and methyl aniline to generate the corresponding N-benzyl-N-methyl aniline.
3. Reaction of N-benzyl-N-methylaniline with diphenyl sulfoxide to produce (1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine.
Safety Information:
Based on the available information, there are currently no clear reports of toxicity and danger for (1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine. However, when using chemicals, it is still necessary to follow laboratory safety procedures and wear appropriate protective equipment. When using or handling the compound, avoid contact with skin and eyes, and maintain a well-ventilated environment. If ingestion or contact is unexpected, seek medical attention immediately and show the details of the chemical to the doctor.
Nature:
-Appearance: colorless or light yellow liquid
-Melting point: about 15-19 degrees Celsius
-Boiling point: about 446-448 degrees Celsius
-Density: approx. 1.096g/cm3
-Solubility: Soluble in organic solvents such as ethanol, dimethylformamide and dimethyl sulfoxide.
Use:
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine are often used as chiral catalysts in organic synthesis reactions. It can participate in various reactions including asymmetric reduction, cyclization, arylation, etc.
Preparation Method:
(1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine can be synthesized in many ways. One of the common methods is to reduce the diphenyl sulfoxide on the chiral meta nitrogen. The specific steps are as follows:
1. the reaction of benzaldehyde and methanol to generate benzyl methanol.
2. the reaction of benzyl methanol and methyl aniline to generate the corresponding N-benzyl-N-methyl aniline.
3. Reaction of N-benzyl-N-methylaniline with diphenyl sulfoxide to produce (1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine.
Safety Information:
Based on the available information, there are currently no clear reports of toxicity and danger for (1R,2R)-1,2-Bis(2-methoxyphenyl)ethylenediamine. However, when using chemicals, it is still necessary to follow laboratory safety procedures and wear appropriate protective equipment. When using or handling the compound, avoid contact with skin and eyes, and maintain a well-ventilated environment. If ingestion or contact is unexpected, seek medical attention immediately and show the details of the chemical to the doctor.
Last Update：2024-04-09 20:15:17
