(1S,3S)-4-Amino-1-adamantanol hydrochloride

(1S,3S)-4-Amino-1-adamantanol hydrochloride - Names and Identifiers

Name	(1S,3S)-4-Amino-1-adamantanol hydrochloride (1:1)
Synonyms	Cis-4-Aminoadamantan-1-ol hydrochloride cis-4-AMino-1-HydroadaMantane Hydrochloride (1S,3S)-4-Amino-1-adamantanol hydrochloride (1r,3R,5S,7r)-4-Aminoadamantan-1-ol hydrochloride
CAS	62075-26-7
InChI	InChI=1S/C10H17NO.ClH/c11-9-7-1-6-2-8(9)5-10(12,3-6)4-7;/h6-9,12H,1-5,11H2;1H/t6?,7-,8?,9?,10-;/m0./s1

(1S,3S)-4-Amino-1-adamantanol hydrochloride - Physico-chemical Properties

Molecular Formula	C10H18ClNO
Molar Mass	203.70902
Storage Condition	2-8 ℃, dark

(1S,3S)-4-Amino-1-adamantanol hydrochloride - Introduction

(1S,3S)-4-Amino-1-adamantanol hydrochloride (1:1) ((1S,3S)-4-Amino-1-adamantanol hydrochloride (1:1)) is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White or off-white crystalline powder
-Molecular formula: C10H18ClNO
-Molar mass of hydrochloride: 227.71g/mol
-Melting Point: 208-214°C
-Solubility: Soluble in water and some organic solvents
- pH: Acidic

Use:
- (1S,3S)-4-Amino-1-adamantanol hydrochloride (1:1) is widely used in the pharmaceutical field and is an important intermediate of antiviral and antitumor drugs.
-It can be used to synthesize a variety of biologically active compounds, such as anti-HIV drugs.

Preparation Method:
- (1S,3S)-4-Amino-1-adamantanol hydrochloride (1:1) is usually synthesized by the following steps:
1. react adamantane (adamantane) with tert-butyl ammonium bromide (tert-butylammonium bromide) to generate tert-butyl salt of adamantane.
2. The tert-butyl salt was hydrolyzed with sodium hydroxide (NaOH) to give 1-hexanone.
3. The hexanone derivative of adamantane is obtained by reacting 1-hexanone with ammonia water.
4. Finally, the obtained hexanone derivative was reacted with hydrochloric acid to produce (1S,3S)-4-Amino-1-adamantanol hydrochloride (1:1).

Safety Information:
- (1S,3S)-4-Amino-1-adamantanol hydrochloride (1:1) is considered relatively safe under general conditions of use. However, it is still necessary to pay attention to the following safety matters according to the specific situation:
1. Avoid inhalation of dust and contact with skin, eyes and clothing.
2. Use chemical protective gloves and goggles to protect yourself.
3. in the use of the compound, should follow the laboratory safety procedures.
4. Keep dry during storage and avoid contact with oxidizing agents.

Last Update：2024-04-09 21:00:56