(2-氯-5-碘苯基)(4-氟苯基)甲酮(依帕列净中间体)
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
CAS: 915095-86-2
Molecular Formula: C13H7ClFIO
(2-氯-5-碘苯基)(4-氟苯基)甲酮(依帕列净中间体) - Names and Identifiers
(2-氯-5-碘苯基)(4-氟苯基)甲酮(依帕列净中间体) - Physico-chemical Properties
| Molecular Formula | C13H7ClFIO |
| Molar Mass | 360.55 |
| Density | 1.752 |
| Melting Point | 64-70oC |
| Boling Point | 415℃ |
| Flash Point | 205℃ |
| Solubility | Chloroform (Slightly), Ethyl Acetate |
| Appearance | Solid |
| Color | Off-White |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
(2-氯-5-碘苯基)(4-氟苯基)甲酮(依帕列净中间体) - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29142990 |
(2-氯-5-碘苯基)(4-氟苯基)甲酮(依帕列净中间体) - Reference Information
| Overview | (2-chloro-5-iodophenyl) (4-fluorophenyl) methanone is an intermediate in the synthesis of empagliflozin. Empagliflozin, a type 2 sodium glucose cotransporter inhibitor, was developed by Boehringer Ingelheim and Lee. SGLT-2 inhibitor is a new type of hypoglycemic drug, mainly by inhibiting the expression of SGLT-2 in the kidney, reduce the renal reabsorption of glucose, increase the excretion of glucose in the urine, thereby reducing plasma glucose levels, its hypoglycemic effect does not depend on β-cell function and insulin resistance. |
Last Update：2024-04-09 21:54:55
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